8A66 Chain A
Serine/threonine-protein kinase 3 (STK3)
Active — 99.8%DFG-inαC-inType1 · 5BS
Resolution
1.901 Å
R-value
0.22
Predicted activity confidence99.8%
Structure info
Alternate conformationB
Missing atoms0
Missing residues4
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EEVFDVLEKLGGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTAKRNVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHE
UniProt reference sequence
FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI
Aligned reference sequence
FDVL----------------EKLGEGS----------------YGSVFKAIH--KE------------------------------------SGQVVAIKQVP--VESD------------------------------LQEIIKEISIMQQC--------------------------DSPYVVKYYGSYFKNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLWIVMEYCGA--------------GSVSDIIRL--RNK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLIEDEIATILKSTLKGLEYLHFM---------------------------------------------RKIHRDI-----KAGNILLNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHAKLADFGVAGQLTDTMAK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTVIGTPFWMAPEVIQE--------------------------------IGYN-CVADIWSLGITSIEMAEG-----------------KPPYAD--------------------------------------------------IHPMRAIFMIPTN--PPPTFRKPELWS---------------------------------------------------------------------------------------------------DDFTDFVKKCLVKNPEQRAT--------------ATQLLQHPFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FDVL----------------EKLG--------------------GSVFKAIH--KE------------------------------------SGQVVAIKQVP--VESD------------------------------LQEIIKEISIMQQC--------------------------DSPYVVKYYGSYFKNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLWIVMEYCGA--------------GSVSDIIRL--RNK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLIEDEIATILKSTLKGLEYLHFM---------------------------------------------RKIHRDI-----KAGNILLNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHAKLADFGVAGQLTDT-AK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-VIGTPFWMAPEVIQE--------------------------------IGYN-CVADIWSLGITSIEMAEG-----------------KPPYAD--------------------------------------------------IHPMRAIFMIPTN--PPPTFRKPELWS---------------------------------------------------------------------------------------------------DDFTDFVKKCLVKNPEQRAT--------------ATQLLQHPFI
Activation segment
DFGVAGQLTDT-AK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-VIGTPFWMAPE
Binding pocket
EKLG____GSVFKVAIKQVEIIKEISIMQQCDPYVVKYYGSWIVMEYCGAGSVSDIIRLYLHFMRKIHRDIKAGNILLLADFGVA
Ligand info
Orthosteric ligand
5BS
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 8A66, Chain A