7ZYO Chain A
Casein kinase II subunit alpha (CSNK2A1)
Active — 99.9%DFG-inαC-inATPlike,Allosteric,Allosteric · ATP
Resolution
1.58 Å
R-value
0.176
Predicted activity confidence99.9%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVAAAKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK
UniProt reference sequence
YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF
Aligned reference sequence
YQLV----------------RKLGRGK----------------YSEVFEAIN--IT------------------------------------NNEKVVVKILK--PVK-------------------------------KKKIKREIKILENL--R-----------------------GGPNIITLADIVKDPV--SR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPALVFEHVNN--------------TDFKQLYQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLTDYDIRFYMYEILKALDYCHSM---------------------------------------------GIMHRDV-----KPHNVMIDH--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HRKLRLIDWGLAEFYHPGQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPELLVD--Y-----------------------------QMYD-YSLDMWSLGCMLASMIFR--K--------------EPFFHG--------------------------------------------------HDNYDQLVRIAKV--LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVS-----------------------------------------------------------------PEALDFLDKLLRYDHQSRLT--------------AREAMEHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQLV----------------RKLGRGK----------------YSEVFEAIN--IT------------------------------------NNEKVVVKILK--PVA-------------------------------AAKIKREIKILENL--R-----------------------GGPNIITLADIVKDPV--SR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPALVFEHVNN--------------TDFKQLYQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLTDYDIRFYMYEILKALDYCHSM---------------------------------------------GIMHRDV-----KPHNVMIDH--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HRKLRLIDWGLAEFYHPGQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPELLVD--Y-----------------------------QMYD-YSLDMWSLGCMLASMIFR--K--------------EPFFHG--------------------------------------------------HDNYDQLVRIAKV--LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVS-----------------------------------------------------------------PEALDFLDKLLRYDHQSRLT--------------AREAMEHPYF
Activation segment
DWGLAEFYHPGQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPE
Binding pocket
RKLGRGKYSEVFEVVVKILKIKREIKILENLRPNIITLADIALVFEHVN_NTDFKQ__LYCHSMGIMHRDVKPHNVMILIDWGLA
Ligand info
Orthosteric ligand
ATP
Allosteric ligand
KEX
Ligand typeATPlike,Allosteric,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7ZYO, Chain A