7YAW Chain A
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20)
Inactive — 13.2%DFG-inαC-outType1.5_Back · IGS
Resolution
2.1 Å
R-value
0.208
Predicted activity confidence13.2%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
FVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLER
UniProt reference sequence
LQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILES
Aligned reference sequence
LQFF----------------ENCGGGS----------------FGSVYRAKW--IS------------------------------------QDKEVAVKKLL--------------------------------------KIEKEAEILSVL--------------------------SHRNIIQFYGVILEPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYGIVTEYASL--------------GSLYDYINS--NRSE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMDMDHIMTWATDVAKGMHYLHME--APV----------------------------------------KVIHRDL-----KSRNVVIAA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGVLKICDFGASRFHNHTTH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSLVGTFPWMAPEVIQS--------------------------------LPVS-ETCDTYSYGVVLWEMLTR-----------------EVPFKG--------------------------------------------------LEGLQVAWLVVEK--NERLTIPSSCP----------------------------------------------------------------------------------------------------RSFAELLHQCWEADAKKRPS--------------FKQIISILES
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LQFF----------------ENCGGGS----------------FGSVYRAKW--IS------------------------------------QDKEVAVKKLL--------------------------------------KIEKEAEILSVL--------------------------SHRNIIQFYGVILEPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYGIVTEYASL--------------GSLYDYINS--NRSE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMDMDHIMTWATDVAKGMHYLHME--APV----------------------------------------KVIHRDL-----KSRNVVIAA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGVLKICDFGASRFHNHTTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLVGTFPWMAPEVIQS--------------------------------LPVS-ETCDTYSYGVVLWEMLTR-----------------EVPFKG--------------------------------------------------LEGLQVAWLVVEK--NERLTIPSSCP----------------------------------------------------------------------------------------------------RSFAELLHQCWEADAKKRPS--------------FKQIISILES
Activation segment
DFGASRFHNHTTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLVGTFPWMAPE
Binding pocket
ENCGGGSFGSVYRVAVKKLKIEKEAEILSVLSRNIIQFYGVGIVTEYASLGSLYDYINSMEAPVKVIHRDLKSRNVVIICDFGAS
Ligand info
Orthosteric ligand
IGS
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7YAW, Chain A