7XZR Chain A
TRAF2 and NCK-interacting protein kinase (TNIK)
Active — 95.9%DFG-inαC-inType1.5_Front · ANP
Resolution
2.26 Å
R-value
0.184
Predicted activity confidence95.9%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRVGRRNFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTK
UniProt reference sequence
FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI
Aligned reference sequence
FELV----------------ELVGNGT----------------YGQVYKGRH--VK------------------------------------TGQLAAIKVMD--VTGDE-----------------------------EEEIKQEINMLKKY--S-----------------------HHRNIATYYGAFIKKN--PPGMDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSVTDLIKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEEWIAYICREILRGLSHLHQH---------------------------------------------KVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFGVSAQLDRTVGR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPEVIAC--DENPD-------------------------ATYD-FKSDLWSLGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PAPRLKSKKWS----------------------------------------------------------------------------------------------------KKFQSFIESCLVKNHSQRPA--------------TEQLMKHPFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELV----------------ELVGNGT----------------YGQVYKGRH--VK------------------------------------TGQLAAIKVMD--VTGDE-----------------------------EEEIKQEINMLKKY--S-----------------------HHRNIATYYGAFIKKN--PPGMDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSVTDLIKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEEWIAYICREILRGLSHLHQH---------------------------------------------KVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFGVSAQLDR-VGR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-FIGTPYWMAPEVIAC--DENPD-------------------------ATYD-FKSDLWSLGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PAPRLKSKKWS----------------------------------------------------------------------------------------------------KKFQSFIESCLVKNHSQRPA--------------TEQLMKHPFI
Activation segment
DFGVSAQLDR-VGR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-FIGTPYWMAPE
Binding pocket
ELVGNGTYGQVYKAAIKVMEIKQEINMLKKYSRNIATYYGAWLVMEFCGAGSVTDLIKNHLHQHKVIHRDIKGQNVLLLVDFGVS
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeType1.5_Front
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7XZR, Chain A