7VTO Chain A
Serine/threonine-protein kinase PAK 1 (PAK1)
Active — 99.3%DFG-inαC-inType1 · 107
Resolution
2.59 Å
R-value
0.236
Predicted activity confidence99.3%
Structure info
Alternate conformationB
Missing atoms12
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
LRSIVKIGQGASGTVYTAMDVATGQEVAIKQPKKELIINEILVMRENKNPNIVNYLDSYLWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK
UniProt reference sequence
YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL
Aligned reference sequence
YTRF----------------EKIGQGA----------------SGTVYTAMD--VA------------------------------------TGQEVAIKQMN--LQQQPK----------------------------KELIINEILVMREN--------------------------KNPNIVNYLDSYLVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEYLAG--------------GSLTDVVTE--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALEFLHSN---------------------------------------------QVIHRDI-----KSDNILLGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSVKLTDFGFCAQITPEQSK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STMVGTPYWMAPEVVTR--------------------------------KAYG-PKVDIWSLGIMAIEMIEG-----------------EPPYLN--------------------------------------------------ENPLRALYLIATN--GTPELQNPEKLS---------------------------------------------------------------------------------------------------AIFRDFLNRCLEMDVEKRGS--------------AKELLQHQFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LRSI----------------VKIGQGA----------------SGTVYTAMD--VA------------------------------------TGQEVAIK--------QPK----------------------------KELIINEILVMREN--------------------------KNPNIVNYLDSY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LWVVMEYLAG--------------GSLTDVVTE--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALEFLHSN---------------------------------------------QVIHRNI-----KSDNILLGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSVKLTDFGFCAQITPEQSK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-MVGTPYWMAPEVVTR--------------------------------KAYG-PKVDIWSLGIMAIEMIEG-----------------EPPYLN--------------------------------------------------ENPLRALYLIATN--GTPELQNPEKLS---------------------------------------------------------------------------------------------------AIFRDFLNRCLEMDVEKRGS--------------AKELLQHQFL
Activation segment
DFGFCAQITPEQSK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-MVGTPYWMAPE
Binding pocket
_KIGQGASGTVYTVAIKQ_LIINEILVMRENKPNIVNYLDSWVVMEYLAGGSLTDVVTEFLHSNQVIHRNIKSDNILLLTDFGFC
Ligand info
Orthosteric ligand
107
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7VTO, Chain A