7VRE Chain A
Epidermal growth factor receptor (EGFR)
Inactive — 11.2%DFG-inαC-inType1 · 7VH
Resolution
2.507 Å
R-value
0.203
Predicted activity confidence11.2%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAAAKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLI
UniProt reference sequence
FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSK
Aligned reference sequence
FKKI----------------KVLGSGA----------------FGTVYKGLW--IPEGEK--------------------------------VKIPVAIKELR--EATSPKA---------------------------NKEILDEAYVMASV--------------------------DNPHVCRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLITQLMPF--------------GCLLDYVRE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQYLLNWCVQIAKGMNYLEDR---------------------------------------------RLVHRDL-----AARNVLVKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQHVKITDFGLAKLLGAEEKE--YHA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGGKVPIKWMALESILH--------------------------------RIYT-HQSDVWSYGVTVWELMTF--G--------------SKPYDG--------------------------------------------------IPASEISSILEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK--------------FRELIIEFSK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKKI----------------KVLGSGA----------------FGTVYKGLW--IPEGEK--------------------------------VKIPVAIKELR-----SPKA---------------------------NKEILDEAYVMASV--------------------------DNPHVCRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLIMQLMPF--------------GSLLDYVRE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQYLLNWCVQIAKGMNYLEDR---------------------------------------------RLVHRDL-----AARNVLVKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQHVKITDFGLAKLLGA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAKVPIKWMALESILH--------------------------------RIYT-HQSDVWSYGVTVWELMTF--G--------------SKPYDG--------------------------------------------------IPASEISSILEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK--------------FRELIIEFSK
Activation segment
DFGLAKLLGA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAKVPIKWMALE
Binding pocket
KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLIMQLMPFGSLLDYVREYLEDRRLVHRDLAARNVLVITDFGLA
Ligand info
Orthosteric ligand
7VH
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7VRE, Chain A