7V3S Chain A
Hepatocyte growth factor receptor (MET)
Inactive — 0.5%DFG-outαC-inType2 · 5I9
Resolution
1.9 Å
R-value
0.166
Predicted activity confidence0.5%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMEYYAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG
UniProt reference sequence
LIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISA
Aligned reference sequence
LIVH--FN------------EVIGRGH----------------FGCVYHGTL--LDNDG---------------------------------KKIHCAVKSLN--RITDIGE---------------------------VSQFLTEGIIMKDF--------------------------SHPNVLSLLGICLRSE--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPLVVLPYMKH--------------GDLRNFIRN--ETH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPTVKDLIGFGLQVAKGMKYLASK---------------------------------------------KFVHRDL-----AARNCMLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTVKVADFGLARDMYDKEYY--SVHNK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGAKLPVKWMALESLQT--------------------------------QKFT-TKSDVWSFGVLLWELMTR--G--------------APPYPD--------------------------------------------------VNTFDITVYLLQG--RRLLQPEYCP-----------------------------------------------------------------------------------------------------DPLYEVMLKCWHPKAEMRPS--------------FSELVSRISA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LIVH--FN------------EVIGRGH----------------FGCVYHGTL--LDNDG---------------------------------KKIHCAVKSLN--RITDIGE---------------------------VSQFLTEGIIMKDF--------------------------SHPNVLSLLGICLRSE--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPLVVLPYMKH--------------GDLRNFIRN--ETH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPTVKDLIGFGLQVAKGMKYLASK---------------------------------------------KFVHRDL-----AARNCMLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTVKVADFGLARDM---EYY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKLPVKWMALESLQT--------------------------------QKFT-TKSDVWSFGVLLWELMTR--G--------------APPYPD--------------------------------------------------VNTFDITVYLLQG--RRLLQPEYCP-----------------------------------------------------------------------------------------------------DPLYEVMLKCWHPKAEMRPS--------------FSELVSRISA
Activation segment
DFGLARDM---EYY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKLPVKWMALE
Binding pocket
EVIGRGHFGCVYHCAVKSLQFLTEGIIMKDFSPNVLSLLGILVVLPYMKHGDLRNFIRNYLASKKFVHRDLAARNCMLVADFGLA
Ligand info
Orthosteric ligand
5I9
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7V3S, Chain A