7UYU Chain A
Non-receptor tyrosine-protein kinase TYK2 (TYK2)
Inactive — 0.0%DFG-inαC-inType1 · OV0
Resolution
2.05 Å
R-value
0.227
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms31
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALRSGWKQEIDILRTLYHEHIIKYKGCCEDLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPHERVSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQ
UniProt reference sequence
ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTR
Aligned reference sequence
ITQL----------------SHLGQGT----------------RTNVYEGRL--RVEGSGDPEEGKMDDEDPLVPGRDRG------------QELRVVLKVLD--PSHHDI----------------------------ALAFYETASLMSQV--------------------------SHTHLAFVHGVCVRGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENIMVTEYVEH--------------GPLDVWLRR--ERG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVPMAWKMVVAQQLASALSYLENK---------------------------------------------NLVHGNV-----CGRNILLAR--LGLAEGT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPFIKLSDPGVGLGALSR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EERVERIPWLAPECLPG--GA----------------------------NSLS-TAMDKWGFGATLLEICFD--G--------------EAPLQS--------------------------------------------------RSPSEKEHFYQRQ--HRLPEPSC-------------------------------------------------------------------------------------------------------PQLATLTSQCLTYEPTQRPS--------------FRTILRDLTR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
PT------------------------V----------------FHKRYLKKI--RDLGEGHFGKVSLYCYDPTNDG--TG------------EMVAVKLRSGW--KQEIDI----------------------------LRTLY------------------------------------HEHIIKYKGCC---E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLQLVMEYVPL--------------GSLRDYL----PRH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQ---------------------------------------------HYIHRDL-----AARNVLLDN--DRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKIGD--FGLAKAVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HERVSPVFWYAPECL----KE----------------------------YKFY-YASDVWSFGVTLYE---L--L--------------THCDSS--------------------------------------------------QSPPTKTELLERG--ERLPRPDC-------------------------------------------------------------------------------------------------------PCEVYLMKNCWETEASFRPT--------------FENLIPILYQ
Activation segment
D--FGLAKAVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HERVSPVFWYAPE
Binding pocket
RDLGEGHFGKVSLVAVKALGWKQEIDILRTLYEHIIKYKGCQLVMEYVPLGSLRDYLPRYLHAQHYIHRDLAARNVLLIGDFGLA
Ligand info
Orthosteric ligand
OV0
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7UYU, Chain A