7UY3 Chain A
Tyrosine-protein kinase Fgr (FGR)
Inactive — 0.3%DFG-outαC-inType2 · OJL
Resolution
2.99 Å
R-value
0.207
Predicted activity confidence0.3%
Structure info
Alternate conformation—
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQEEIP
UniProt reference sequence
ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLED
Aligned reference sequence
ITLE----------------RRLGTGC----------------FGDVWLGTW--N-------------------------------------GSTKVAVKTLK--PGTMS-----------------------------PKAFLEEAQVMKLL--------------------------RHDKLVQLYAVVSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEFMCH--------------GSLLDFLKN--PEGQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLRLPQLVDMAAQVAEGMAYMERM---------------------------------------------NYIHRDL-----RAANILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLACKIADFGLARLIKDDEYN--PC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGSKFPIKWTAPEAALF--------------------------------GRFT-IKSDVWSFGILLTELITK--G--------------RIPYPG--------------------------------------------------MNKREVLEQVEQG--YHMPCPPGCP-----------------------------------------------------------------------------------------------------ASLYEAMEQTWRLDPEERPT--------------FEYLQSFLED
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLE----------------RRLGTGC----------------FGDVWLGTW--N-------------------------------------GSTKVAVKTLK--PGTMS-----------------------------PKAFLEEAQVMKLL--------------------------RHDKLVQLYAVVSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEFMCH--------------GSLLDFLKN--PEGQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLRLPQLVDMAAQVAEGMAYMERM---------------------------------------------NYIHRDL-----RAANILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLACKIADFGLARLIKDDEYN--PC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG--FPIKWTAPEAALF--------------------------------GRFT-IKSDVWSFGILLTELITK--G--------------RIPYPG--------------------------------------------------MNKREVLEQVEQG--YHMPCPPGCP-----------------------------------------------------------------------------------------------------ASLYEAMEQTWRLDPEERPT--------------FEYLQSFLED
Activation segment
DFGLARLIKDDEYN--PC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG--FPIKWTAPE
Binding pocket
RRLGTGCFGDVWLVAVKTLAFLEEAQVMKLLRDKLVQLYAVYIVTEFMCHGSLLDFLKNYMERMNYIHRDLRAANILVIADFGLA
Ligand info
Orthosteric ligand
OJL
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7UY3, Chain A