7UY0 Chain B
Tyrosine-protein kinase Fgr (FGR)
Inactive — 0.0%DFG-inαC-outType1.5_Back · VSE
Resolution
2.55 Å
R-value
0.188
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms4
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
TLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQEEIP
UniProt reference sequence
ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLED
Aligned reference sequence
ITLE----------------RRLGTGC----------------FGDVWLGTW--N-------------------------------------GSTKVAVKTLK--PGTMS-----------------------------PKAFLEEAQVMKLL--------------------------RHDKLVQLYAVVSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEFMCH--------------GSLLDFLKN--PEGQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLRLPQLVDMAAQVAEGMAYMERM---------------------------------------------NYIHRDL-----RAANILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLACKIADFGLARLIKDDEYN--PC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGSKFPIKWTAPEAALF--------------------------------GRFT-IKSDVWSFGILLTELITK--G--------------RIPYPG--------------------------------------------------MNKREVLEQVEQG--YHMPCPPGCP-----------------------------------------------------------------------------------------------------ASLYEAMEQTWRLDPEERPT--------------FEYLQSFLED
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLE----------------RRLGTGC----------------FGDVWLGTW--N-------------------------------------GSTKVAVKTLK--PGTMS-----------------------------PKAFLEEAQVMKLL--------------------------RHDKLVQLYAVVSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEFM-H--------------GSLLDFLKN--PEGQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLRLPQLVDMAAQVAEGMAYMERM---------------------------------------------NYIHRDL-----RAANILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLACKIADFGLARLIKDDEYN--PC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGSKFPIKWTAPEAALF--------------------------------GRFT-IKSDVWSFGILLTELITK--G--------------RIPYPG--------------------------------------------------MNKREVLEQVEQG--YHMPCPPGCP-----------------------------------------------------------------------------------------------------ASLYEAMEQTWRLDPEERPT--------------FEYLQSFLED
Activation segment
DFGLARLIKDDEYN--PC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGSKFPIKWTAPE
Binding pocket
RRLGTGCFGDVWLVAVKTLAFLEEAQVMKLLRDKLVQLYAVYIVTEFM_HGSLLDFLKNYMERMNYIHRDLRAANILVIADFGLA
Ligand info
Orthosteric ligand
VSE
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7UY0, Chain B