7UPM Chain A
Tribbles homolog 2 (TRIB2)
Active — 88.7%DFG-inαC-in
Resolution
2.7 Å
R-value
0.207
Predicted activity confidence88.7%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
SHCVSCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEIILGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDF
UniProt reference sequence
YLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEIILGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWF
Aligned reference sequence
YLLL----------------EPL------EGD-------------HVFRAVH--LH------------------------------------SGEELVCKVFD--ISCY------------------------------QESLAPCFCLSAHS-----------------------------NINQITEIILGET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KAYVFFERSY---------------GDMHSFVRT--CK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLREEEAARLFYQIASAVAHCHDG---------------------------------------------GLVLRDL-----KLRKFIFKD--EE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTRVKLESLEDAYILRGDDDS--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDKHGCPAYVSPEILNT--S-----------------------------GSYSGKAADVWSLGVMLYTMLVG-----------------RYPFHD--------------------------------------------------IEPSSLFSKIRRG--QFNIPETLS------------------------------------------------------------------------------------------------------PKAKCLIRSILRREPSERLT--------------SQEILDHPWF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YLLL----------------EPL------EGD-------------HVFRAVH--LH------------------------------------SGEELVCKVFD--ISCY------------------------------QESLAPCFCLSAHS-----------------------------NINQITEIILGET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KAYVFFERSY---------------GDMHSFVRT--CK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLREEEAARLFYQIASAVAHCHDG---------------------------------------------GLVLRDL-----KLRKFIFKD--EE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTRVKLESLEDAYILRGDDDS--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDKHGCPAYVSPEILNT--S-----------------------------GSYSGKAADVWSLGVMLYTMLVG-----------------RYPFHD--------------------------------------------------IEPSSLFSKIRRG--QFNIPETLS------------------------------------------------------------------------------------------------------PKAKCLIRSILRREPSERLT--------------SQEILDHPWF
Activation segment
SLEDAYILRGDDDS--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDKHGCPAYVSPE
Binding pocket
LLLEPLEGDHVFRLVCKVFYQESLAPCFCLSASNINQITEIYVFFERSY_GDMHSFVRTHCHDGGLVLRDLKLRKFIFVKLESLE
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7UPM, Chain A