7UJT Chain A
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)
Inactive — 36.8%DFG-inαC-inATPlike · ATP
Resolution
2.1 Å
R-value
0.205
Predicted activity confidence36.8%
Structure info
Alternate conformation—
Missing atoms8
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR
UniProt reference sequence
YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI
Aligned reference sequence
YQLF----------------EELGKGA----------------FSVVRRCVK--VL------------------------------------AGQEYAAKIIN--TKKLSARD--------------------------HQKLEREARICRLL--------------------------KHPNIVRLHDSISEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHYLIFDLVTG--------------GELFEDIVA--RE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYSEADASHCIQQILEAVLHCHQM---------------------------------------------GVVHRDL-----KPENLLLAS--KLK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAAVKLADFGLAIEVEGEQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPEVLRK--------------------------------DPYG-KPVDLWACGVILYILLVG-----------------YPPFWD--------------------------------------------------EDQHRLYQQIKAG--AYDFPSPEWDTVT--------------------------------------------------------------------------------------------------PEAKDLINKMLTINPSKRIT--------------AAEALKHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQLF----------------EELGKGA----------------FSVVRRCVK--VL------------------------------------AGQEYAAKIIN--TKKLSARD--------------------------HQKLEREARICRLL--------------------------KHPNIVRLHDSISEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHYLIFDLVTG--------------GELFEDIVA--RE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYSEADASHCIQQILEAVLHCHQM---------------------------------------------GVVHRNL-----KPENLLLAS--KLK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAAVKLADFGLAIEVEGEQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPEVLRK--------------------------------DPYG-KPVDLWACGVILYILLVG-----------------YPPFWD--------------------------------------------------EDQHRLYKQIKAG--AYDFPSPEWDTVT--------------------------------------------------------------------------------------------------PEAKDLINKMLTINPSKRIT--------------AAEALKHPWI
Activation segment
DFGLAIEVEGEQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPE
Binding pocket
EELGKGAFSVVRRYAAKIIKLEREARICRLLKPNIVRLHDSYLIFDLVTGGELFEDIVAHCHQMGVVHRNLKPENLLLLADFGLA
Ligand info
Orthosteric ligand
ATP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7UJT, Chain A