7SZR Chain A
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)
Active — 82.0%DFG-inαC-inType1.5_Back · DYQ
Resolution
2.8 Å
R-value
0.231
Predicted activity confidence82.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PVEEYLVHALQGSVSSGQAHSLASLAKTWSDNEGVLLTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKVGKALQEVGGLKSPWKGEYKEPR
UniProt reference sequence
WATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNR
Aligned reference sequence
WATH--Q-------------LRLGRGS----------------FGEVHRMED--KQ------------------------------------TGFQCAVKKVR--L---------------------------------EVFRAEELMACAGL--------------------------TSPRIVPLYGAVREGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WVNIFMELLEG--------------GSLGQLVKE--QG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLPEDRALYYLGQALEGLEYLHSR---------------------------------------------RILHGDV-----KADNVLLSS--D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSHAALCDFGHAVCLQPDGLG--KSLLTG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DYIPGTETHMAPEVVLG--------------------------------RSCD-AKVDVWSSCCMMLHMLNG-----------------CHPWTQ--------------------------------------------------FFRGPLCLKIASE--PPPVREIPPSCA---------------------------------------------------------------------------------------------------PLTAQAIQEGLRKEPIHRVS--------------AAELGGKVNR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WMTH--Q-------------PRVGRGS----------------FGEVHRMKD--KQ------------------------------------TGFQCAVKKVR--L---------------------------------EVFRVEELVACAGL--------------------------SSPRIVPLYGAVREGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WVNIFMELLEG--------------GSLGQLIKQ--MG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLPEDRALYYLGQALEGLEYLHTR---------------------------------------------RILHGDV-----KADNVLLSS--D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSRAALCDFGHALCLQP-------SLLTG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DYIPGTETHMAPEVVMG--------------------------------KPCD-AKVDIWSSCCMMLHMLNG-----------------CHPWTQ--------------------------------------------------YF--PLCLKIASE--PPPIREIPPSCA---------------------------------------------------------------------------------------------------PLTAQAIQEGLRKEPVHRAS--------------AMELRRKVPR
Activation segment
DFGHALCLQP-------SLLTG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DYIPGTETHMAPE
Binding pocket
PRVGRGSFGEVHRCAVKKVFRVEELVACAGLSPRIVPLYGANIFMELLEGGSLGQLIKQYLHTRRILHGDVKADNVLLLCDFGHA
Ligand info
Orthosteric ligand
DYQ
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7SZR, Chain A