7SZC Chain A
EKC/KEOPS complex subunit TP53RK (TP53RK)
Active — 96.8%DFG-inαC-inType1 · DO0
Resolution
1.71 Å
R-value
0.179
Predicted activity confidence96.8%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EAEALAAARERSSRFLSGLELVKQGAEARVFRGRFQGRAAVIKHRFPKGYRHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIEGSVTVRDYIQSTMETEKTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLKPPLEQLNIVLIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETVFEAFLKSYSTSSKKARPVLKKLDEVRLRG
UniProt reference sequence
LSGLELVKQGAEARVFRGRFQGRAAVIKHRFPKGYRHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIEGSVTVRDYIQSTMETEKTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLKPPLEQLNIVLIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETVFEAFLKSYSTSSKKARPVLKKLDEVRLRGRKRSMVG
Aligned reference sequence
LSGL----------------ELVKQGA----------------EARVFRGRF----------------------------------------QGRAAVIKHRF--PKGYRHPALEARLG--------------------RRRTVQEARALLRC--R-----------------------RAGISAPVVFFVDYAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCLYMEEIEGS--------------VTVRDYIQS--TMET-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKTPQGLSNLAKTIGQVLARMHDE---------------------------------------------DLIHGDL-----TTSNMLLKP--PLE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLNIVLIDFGLSFISA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPEDKGVDLYVLEKAFL--------------------------------STHPNTETVFEAFLKSYSTSSKK----------------------------------------------------------------------------------------ARPVLKKLDEVRLRGRKRSMVG-------------------------------------------------------------------------------------------------------------------------------------
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LSGL----------------ELVKQGA----------------EARVFRGRF----------------------------------------QGRAAVIKHRF--PKGYRHPALEARLG--------------------RRRTVQEARALLRC--R-----------------------RAGISAPVVFFVDYAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCLYMEEIEGS--------------VTVRDYIQS--TMET-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKTPQGLSNLAKTIGQVLARMHDE---------------------------------------------DLIHGDL-----TTSNMLLKP--PLE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLNIVLIDFGLSFISA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPEDKGVDLYVLEKAFL--------------------------------STHPNTETVFEAFLKSYSTSSKK----------------------------------------------------------------------------------------ARPVLKKLDEVRLR-------G-------------------------------------------------------------------------------------------------------------------------------------
Activation segment
DFGLSFISA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPEDKGVDLYVLE
Binding pocket
ELVKQGAEARVFRAVIKHRRTVQEARALLRCRAGISAPVVFCLYMEEIE_GSVTVRDYIRMHDEDLIHGDLTTSNMLLLIDFGLS
Ligand info
Orthosteric ligand
DO0
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7SZC, Chain A