7SXG Chain A
Glycogen synthase kinase-3 alpha (GSK3A)
Active — 66.5%DFG-inαC-inType1 · D1E
Resolution
2.4 Å
R-value
0.233
Predicted activity confidence66.5%
Structure info
Alternate conformationA
Missing atoms21
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
VVATLGQPEREVAYTDIKVIGNGSFGVVYQARLRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHL
UniProt reference sequence
YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
Aligned reference sequence
YTDI----------------KVIGNGS----------------FGVVYQARL--AE------------------------------------TRELVAIKKVL--QD--------------------------------KRFKNRELQIMRKL--------------------------DHCNIVRLRYFFYSSG--EKKDEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLNLVLEYVP---------------ETVYRVARH--FTKAKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIPILYVKVYMYQLFRSLAYIHSQ---------------------------------------------GVCHRDI-----KPQNLLVDP--D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAVLKLCDFGSAKQLVRGEPN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSYICSRYYRAPELIFG--A-----------------------------TDYT-SSIDVWSAGCVLAELLLG-----------------QPIFPG--------------------------------------------------DSGVDQLVEIIKV--LGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTP-------------------------------------------------------------------------PEAIALCSSLLEYTPSSRLS--------------PLEACAHSFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YTDI----------------KVIGNGS----------------FGVVYQARL-----------------------------------------RELVAIKKVL--QD--------------------------------KRFKNRELQIMRKL--------------------------DHCNIVRLRYFFYSSG--E---EL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLNLVLEYVP---------------ETVYRVARH--FTKAKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIPILYVKVYMYQLFRSLAYIHSQ---------------------------------------------GVCHRDI-----KPQNLLVDP--D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAVLKLCDFGSAKQLVRGEPN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VS-ICSRYYRAPELIFG--A-----------------------------TDYT-SSIDVWSAGCVLAELLLG-----------------QPIFPG--------------------------------------------------DSGVDQLVEIIKV--LGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTP-------------------------------------------------------------------------PEAIALCSSLLEYTPSSRLS--------------PLEACAHSFF
Activation segment
DFGSAKQLVRGEPN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VS-ICSRYYRAPE
Binding pocket
KVIGNGSFGVVYQVAIKKVFKNRELQIMRKLDCNIVRLRYFNLVLEYVP_ETVYRVARHYIHSQGVCHRDIKPQNLLVLCDFGSA
Ligand info
Orthosteric ligand
D1E
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7SXG, Chain A