7SXF Chain A
Glycogen synthase kinase-3 alpha (GSK3A)
Active — 62.6%DFG-inαC-inType1 · 6VL
Resolution
1.94 Å
R-value
0.203
Predicted activity confidence62.6%
Structure info
Alternate conformationB
Missing atoms10
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
TTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHR
UniProt reference sequence
YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
Aligned reference sequence
YTDI----------------KVIGNGS----------------FGVVYQARL--AE------------------------------------TRELVAIKKVL--QD--------------------------------KRFKNRELQIMRKL--------------------------DHCNIVRLRYFFYSSG--EKKDEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLNLVLEYVP---------------ETVYRVARH--FTKAKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIPILYVKVYMYQLFRSLAYIHSQ---------------------------------------------GVCHRDI-----KPQNLLVDP--D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAVLKLCDFGSAKQLVRGEPN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSYICSRYYRAPELIFG--A-----------------------------TDYT-SSIDVWSAGCVLAELLLG-----------------QPIFPG--------------------------------------------------DSGVDQLVEIIKV--LGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTP-------------------------------------------------------------------------PEAIALCSSLLEYTPSSRLS--------------PLEACAHSFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YTDI----------------KVIGNGS----------------FGVVYQARL-----------------------------------------RELVAIKKVL--QD--------------------------------KRFKNRELQIMRKL--------------------------DHCNIVRLRYFFYSSG--E--DEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLNLVLEYVP---------------ETVYRVARH--FTKAKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIPILYVKVYMYQLFRSLAYIHSQ---------------------------------------------GVCHRDI-----KPQNLLVDP--D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAVLKLCDFGSAKQLVRGEPN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VS-ICSRYYRAPELIFG--A-----------------------------TDYT-SSIDVWSAGCVLAELLLG-----------------QPIFPG--------------------------------------------------DSGVDQLVEIIKV--LGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTP-------------------------------------------------------------------------PEAIALCSSLLEYTPSSRLS--------------PLEACAHSFF
Activation segment
DFGSAKQLVRGEPN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VS-ICSRYYRAPE
Binding pocket
KVIGNGSFGVVYQVAIKKVFKNRELQIMRKLDCNIVRLRYFNLVLEYVP_ETVYRVARHYIHSQGVCHRDIKPQNLLVLCDFGSA
Ligand info
Orthosteric ligand
6VL
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7SXF, Chain A