7SJ3 Chain A
Cyclin-dependent kinase 4 (CDK4)
Active — 99.9%DFG-inαC-inType1 · 6ZV
Resolution
2.51 Å
R-value
0.201
Predicted activity confidence99.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSDREIKVTLVFEHVDQDLRTYLDKAPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
UniProt reference sequence
YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
Aligned reference sequence
YEPV----------------AEIGVGA----------------YGTVYKARD--PH------------------------------------SGHFVALKSVR--VPNGGGGGGGL-----------------------PISTVREVALLRRL--EAF---------------------EHPNVVRLMDVCATSR--TDREI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVTLVFEHVD---------------QDLRTYLDK--APPP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAETIKDLMRQFLRGLDFLHAN---------------------------------------------CIVHRDL-----KPENILVTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGTVKLADFGLARIYSYQMAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPVVVTLWYRAPEVLLQ--------------------------------STYA-TPVDMWSVGCIFAEMFRR-----------------KPLFCG--------------------------------------------------NSEADQLGKIFDL--IGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEME---------------------------------------------------------------------------ESGAQLLLEMLTFNPHKRIS--------------AFRALQHSYL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEPV----------------AEIGVGA----------------YGTVYKARD--PH------------------------------------SGHFVALKSVR---------GGGL-----------------------PISTVREVALLRRL--EAF---------------------EHPNVVRLMDVCATS----DREI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVTLVFEHVD---------------QDLRTYLDK--A----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAETIKDLMRQFLRGLDFLHAN---------------------------------------------CIVHRDL-----KPENILVTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGTVKLADFGLARIYSYQMAL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVVVTLWYRAPEVLLQ--------------------------------STYA-TPVDMWSVGCIFAEMFRR-----------------KPLFCG--------------------------------------------------NSEADQLGKIFDL--IGLPPEDDWPRDVSLPRGAFPPRGPR------PEME---------------------------------------------------------------------------ESGAQLLLEMLTFNPHKRIS--------------AFRALQHSYL
Activation segment
DFGLARIYSYQMAL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVVVTLWYRAPE
Binding pocket
AEIGVGAYGTVYKVALKSVSTVREVALLRRLEPNVVRLMDVTLVFEHVD_QDLRTYLDKFLHANCIVHRDLKPENILVLADFGLA
Ligand info
Orthosteric ligand
6ZV
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7SJ3, Chain A