7RWE Chain A
Cyclin-dependent kinase 2 (CDK2)
Inactive — 0.0%DFG-inαC-outType1,Type3 · 7TH
Resolution
1.59 Å
R-value
0.217
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms14
Missing residues10
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
NFQKVEKIGGVVYKARNGEVVALKKIISLLKELNHPNIVKLLDVIHTLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
UniProt reference sequence
FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
Aligned reference sequence
FQKV----------------EKIGEGT----------------YGVVYKARN--KL------------------------------------TGEVVALKKIR--LDTETEGV--------------------------PSTAIREISLLKEL--------------------------NHPNIVKLLDVIHTEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLVFEFLH---------------QDLKKFMDA--SALT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH---------------------------------------------RVLHRDL-----KPQNLLINT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAIKLADFGLARAFGVPVRT--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THEVVTLWYRAPEILLG--C-----------------------------KYYS-TAVDIWSLGCIFAEMVTR-----------------RALFPG--------------------------------------------------DSEIDQLFRIFRT--LGTPDEVVWPGVTSMPDYKP-SFPKWARQDFSKVVPPLD------------------------------------------------------------------------EDGRSLLSQMLHYDPNKRIS--------------AKAALAHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FQKV----------------EKIG--------------------GVVYKARN-----------------------------------------GEVVALKKI--------------------------------------------ISLLKEL--------------------------NHPNIVKLLDVIHT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LYLVFEFLH---------------QDLKKFMDA--SALT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH---------------------------------------------RVLHRDL-----KPQNLLINT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAIKLADFGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLWYRAPEILLG--C-----------------------------KYYS-TAVDIWSLGCIFAEMVTR-----------------RALFPG--------------------------------------------------DSEIDQLFRIFRT--LGTPDEVVWPGVTSMPDYKP-SFPKWARQDFSKVVPPLD------------------------------------------------------------------------EDGRSLLSQMLHYDPNKRIS--------------AKAALAHPFF
Activation segment
DFGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLWYRAPE
Binding pocket
EKIG____GVVYKVALKKI_____ISLLKELNPNIVKLLDVYLVFEFLH_QDLKKFMDAFCHSHRVLHRDLKPQNLLILADFGL_
Ligand info
Orthosteric ligand
7TH
Allosteric ligand
None
Ligand typeType1,Type3
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7RWE, Chain A