7QWK Chain A
eIF-2-alpha kinase GCN2 (EIF2AK4)
Inactive — 43.5%DFG-outαC-inType1 · G41
Resolution
2.3 Å
R-value
0.214
Predicted activity confidence43.5%
Structure info
Alternate conformation—
Missing atoms34
Missing residues19
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
FSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRNLKPVNIFLDSDDHVKIGDFGLGTALYVSPEVQGSTYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKS
UniProt reference sequence
VHKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFI
Aligned reference sequence
VHKG----------------KCIGSDE--QL------------GKLVYNALE--TA------------------------------------TGGFVLLYEWV--LQWQKKMGPFLTSQEKEKIDKCKKQ---------IQGTETEFNSLVKL--------------------------SHPNVVRYLAMNLKEQ--DDSI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVDILVEHISG--------------VSLAAHLSH--SG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIPVHQLRRYTAQLLSGLDYLHSN---------------------------------------------SVVHKVL-----SASNVLVDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGTVKITDYSISKRLADICKE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVFEQTRVRFSDNALP---------------------------------YKTG-KKGDVWRLGLLLLSLSQG-------------------------QECG-----------------------------------------------------------EYPVTIPSDLP----------------------------------------------------------------------------------------------------ADFQDFLKKCVCLDDKERWS--------------PQQLLKHSFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FSRY----------------FIEFEEL--QL------------GKGAFGA----------------------------------------------------V--IKVQNKLDGCCYAVKRIPINPASRQ---------FRRIKGEVTLLSRL--------------------------HHENIVRY--YNAWIE--RHVH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYIQMEYCEK--------------STLRDTIDQ--GL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRDTVRLWRLFREILDGLAYIHEK---------------------------------------------GMIHRNL-----KPVNIFLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDHVKIGDFGLGTALTYNQKV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLFSLGIIFFEMSYHP---------------------------------MVT--ASERIFVLNQLRDPTS-------------------------------------------------------------------------------------------------PKFP----------------------------------------------------------------------------------------------------EDFDDAKQKSVNHDPAKRPT--------------ATELLK---S
Activation segment
DFGLGTALTYNQKV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLFSLGIIFFEMS
Binding pocket
QLLGKGAFGAVIKYAVKRIRIKGEVTLLSRLHENIVRYYNA__________________YIHEKGMIHRNLKPVNIFLIGDFGL_
Ligand info
Orthosteric ligand
G41
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7QWK, Chain A