7QUF Chain A
Serine/threonine-protein kinase 17A (STK17A)
Active — 90.4%DFG-inαC-inType1 · F8I
Resolution
2.6 Å
R-value
0.235
Predicted activity confidence90.4%
Structure info
Alternate conformation—
Missing atoms30
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SMVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLT
UniProt reference sequence
YSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWL
Aligned reference sequence
YSLC--PG------------RELGRGK----------------FAVVRKCIK--KD------------------------------------SGKEFAAKFMR--KRRKGQDC--------------------------RMEIIHEIAVLELA--Q-----------------------DNPWVINLHEVYETAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMILVLEYAAG--------------GEIFDQCVA--DREE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFKEKDVQRLMRQILEGVHFLHTR---------------------------------------------DVVHLDL-----KPQNILLTS--ESP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGDIKIVDFGLSRILKNSEEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIMGTPEYVAPEILSY--------------------------------DPIS-MATDMWSIGVLTYVMLTG-----------------ISPFLG--------------------------------------------------NDKQETFLNISQM--NLSYSEEEFDVLS--------------------------------------------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT--------------AEECLKHPWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YSLC--PG------------RELGRGK----------------FAVVRKCIK--KD------------------------------------SGKEFAAKFMR--KRRKGQDC--------------------------RMEIIHEIAVLELA--Q-----------------------DNPWVINLHEVYETAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMILVLEYAAG--------------GEIFDQCV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFKEKDVQRLMRQILEGVHFLHTR---------------------------------------------DVVHLDL-----KPQNILLTS--ESP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGDIKIVDFGLSRILKNSEEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIMGTPEYVAPEILSY--------------------------------DPIS-MATDMWSIGVLTYVMLTG-----------------ISPFLG--------------------------------------------------NDKQETFLNISQM--NLSYSEEEFDVLS--------------------------------------------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT--------------AEECLKHPWL
Activation segment
DFGLSRILKNSEEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIMGTPEYVAPE
Binding pocket
RELGRGKFAVVRKFAAKFMEIIHEIAVLELAQPWVINLHEVILVLEYAAGGEIFDQCV_FLHTRDVVHLDLKPQNILLIVDFGLS
Ligand info
Orthosteric ligand
F8I
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7QUF, Chain A