7QUE Chain A
Serine/threonine-protein kinase 17A (STK17A)
Active — 92.1%DFG-inαC-inType1 · F7I
Resolution
2.4 Å
R-value
0.235
Predicted activity confidence92.1%
Structure info
Alternate conformation—
Missing atoms25
Missing residues5
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SMVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLT
UniProt reference sequence
YSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWL
Aligned reference sequence
YSLC--PG------------RELGRGK----------------FAVVRKCIK--KD------------------------------------SGKEFAAKFMR--KRRKGQDC--------------------------RMEIIHEIAVLELA--Q-----------------------DNPWVINLHEVYETAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMILVLEYAAG--------------GEIFDQCVA--DREE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFKEKDVQRLMRQILEGVHFLHTR---------------------------------------------DVVHLDL-----KPQNILLTS--ESP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGDIKIVDFGLSRILKNSEEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIMGTPEYVAPEILSY--------------------------------DPIS-MATDMWSIGVLTYVMLTG-----------------ISPFLG--------------------------------------------------NDKQETFLNISQM--NLSYSEEEFDVLS--------------------------------------------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT--------------AEECLKHPWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YSLC--PG------------RELGRGK----------------FAVVRKCIK--KD------------------------------------SGKEFAAKFMR--KRRKGQDC--------------------------RMEIIHEIAVLELA--Q-----------------------DNPWVINLHEVYETAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMILVLEYAAG--------------GEIF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFKEKDVQRLMRQILEGVHFLHTR---------------------------------------------DVVHLDL-----KPQNILLTS--ESP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGDIKIVDFGLSRILKNSEEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIMGTPEYVAPEILSY--------------------------------DPIS-MATDMWSIGVLTYVMLTG-----------------ISPFLG--------------------------------------------------NDKQETFLNISQM--NLSYSEEEFDVLS--------------------------------------------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT--------------AEECLKHPWL
Activation segment
DFGLSRILKNSEEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIMGTPEYVAPE
Binding pocket
RELGRGKFAVVRKFAAKFMEIIHEIAVLELAQPWVINLHEVILVLEYAAGGEIF_____FLHTRDVVHLDLKPQNILLIVDFGLS
Ligand info
Orthosteric ligand
F7I
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7QUE, Chain A