7QQ6 Chain A
eIF-2-alpha kinase GCN2 (EIF2AK4)
Active — 56.0%DFG-inαC-inType1 · 38O
Resolution
2.8 Å
R-value
0.213
Predicted activity confidence56.0%
Structure info
Alternate conformation—
Missing atoms10
Missing residues20
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHERPVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRNLKPVNIFLDSDDHVKIGDFGLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPP
UniProt reference sequence
VHKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFI
Aligned reference sequence
VHKG----------------KCIGSDE--QL------------GKLVYNALE--TA------------------------------------TGGFVLLYEWV--LQWQKKMGPFLTSQEKEKIDKCKKQ---------IQGTETEFNSLVKL--------------------------SHPNVVRYLAMNLKEQ--DDSI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVDILVEHISG--------------VSLAAHLSH--SG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIPVHQLRRYTAQLLSGLDYLHSN---------------------------------------------SVVHKVL-----SASNVLVDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGTVKITDYSISKRLADICKE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVFEQTRVRFSDNALP---------------------------------YKTG-KKGDVWRLGLLLLSLSQG-------------------------QECG-----------------------------------------------------------EYPVTIPSDLP----------------------------------------------------------------------------------------------------ADFQDFLKKCVCLDDKERWS--------------PQQLLKHSFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
SRYF----------------IEFEELQ--LL------------GKGAFGA----------------------------------------------------V--IKVQNKLDGCCYAVKRIPINPASRQ---------FRRIKGEVTLLSRL--------------------------HHENIVRYYAWIERHE--RPVH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYIQMEYCEK--------------STLRDTIDQ--GL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRDTVRLWRLFREILDGLAYIHEK---------------------------------------------GMIHRNL-----KPVNIFLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDHVKIGDVQGSTKSAYNQKV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLFSLGIIFFEMSYHP---------------------------------MVT--ASERIFVLNQLRDPTS-------------------------------------------------------------------------------------------------PKFP----------------------------------------------------------------------------------------------------EDFDDAKQKSVNHDPAKRPT--------------ATELLKLPPP
Activation segment
DVQGSTKSAYNQKV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLFSLGIIFFEMS
Binding pocket
QLLGKGAFGAVIKYAVKRIRIKGEVTLLSRLHENIVRYYNA__________________YIHEKGMIHRNLKPVNIFLIGDFG__
Ligand info
Orthosteric ligand
38O
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7QQ6, Chain A