7Q90 Chain A
Tau-tubulin kinase 2 (TTBK2)
Active — 100.0%DFG-inαC-inType1 · 9IS
Resolution
1.6 Å
R-value
0.192
Predicted activity confidence100.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEK
UniProt reference sequence
WKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDN
Aligned reference sequence
WKVL----------------RKIGGGG----------------FGEIYDALD--ML------------------------------------TRENVALKVES--AQQP------------------------------KQVLKMEVAVLKKL--Q-----------------------GKDHVCRFIGCGRNDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FNYVVMQLQG---------------RNLADLRRS--QSRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTISTTLRLGRQILESIESIHSV---------------------------------------------GFLHRDI-----KPSNFAMGR--FPST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CRKCYMLDFGLARQFTNSCGD--VRPPRAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGFRGTVRYASINAHRN--------------------------------REMG-RHDDLWSLFYMLVEFVVG-----------------QLPWRK--I-----------------------------------------------KDKEQVGSIKERY--DHRLMLKHLP-----------------------------------------------------------------------------------------------------PEFSIFLDHISSLDYFTKPD--------------YQLLTSVFDN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WKVL----------------RKIGGGG----------------FGEIYDALD--ML------------------------------------TRENVALKVES--AQQP------------------------------KQVLKMEVAVLKKL--Q-----------------------GKDHVCRFIGCGRNDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FNYVVMQLQG---------------RNLADLRRS--QSRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTISTTLRLGRQILESIESIHSV---------------------------------------------GFLHRDI-----KPSNFAMGR--FPST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CRKCYMLDFGLARQFTNSCGD--VRPPRAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGFRGTVRYASINAHRN--------------------------------REMG-RHDDLWSLFYMLVEFVVG-----------------QLPWRK--I-----------------------------------------------KDKEQVGSIKERY--DHRLMLKHLP-----------------------------------------------------------------------------------------------------PEFSIFLDHISSLDYFTKPD--------------YQLLTSVFDN
Activation segment
DFGLARQFTNSCGD--VRPPRAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGFRGTVRYASIN
Binding pocket
RKIGGGGFGEIYDVALKVEVLKMEVAVLKKLQDHVCRFIGCYVVMQLQG_RNLADLRRSSIHSVGFLHRDIKPSNFAMMLDFGLA
Ligand info
Orthosteric ligand
9IS
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7Q90, Chain A