7Q7D Chain A
Serine/threonine-protein kinase 17B (STK17B)
Active — 98.9%DFG-inαC-inATPlike · ATP
Resolution
2.6 Å
R-value
0.196
Predicted activity confidence98.9%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWD
UniProt reference sequence
YILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWL
Aligned reference sequence
YILT--S-------------KELGRGK----------------FAVVRQCIS--KS------------------------------------TGQEYAAKFLK--KRRRGQDC--------------------------RAEILHEIAVLELA--K-----------------------SCPRVINLHEVYENTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIILILEYAAG--------------GEIFSLCLP--ELAE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSENDVIRLIKQILEGVYYLHQN---------------------------------------------NIVHLDL-----KPQNILLSS--IYP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGDIKIVDFGMSRKIGHACEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIMGTPEYLAPEILNY--------------------------------DPIT-TATDMWNIGIIAYMLLTH-----------------TSPFVG--------------------------------------------------EDNQETYLNISQV--NVDYSEETFSSVS--------------------------------------------------------------------------------------------------QLATDFIQSLLVKNPEKRPT--------------AEICLSHSWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YILT--S-------------KELGRGK----------------FAVVRQCIS--KS------------------------------------TGQEYAAKFLK--KRRRGQDC--------------------------RAEILHEIAVLELA--K-----------------------SCPRVINLHEVYENTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIILILEYAAG--------------GEIFSLCLP--ELAE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSENDVIRLIKQILEGVYYLHQN---------------------------------------------NIVHLDL-----KPQNILLSS--IYP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGDIKIVDFGMSRKIGHACEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIMGTPEYLAPEILNY--------------------------------DPIT-TATDMWNIGIIAYMLLTH-----------------TSPFVG--------------------------------------------------EDNQETYLNISQV--NVDYSEETFSSVS--------------------------------------------------------------------------------------------------QLATDFIQSLLVKNPEKRPT--------------AEICLSHSWL
Activation segment
DFGMSRKIGHACEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIMGTPEYLAPE
Binding pocket
KELGRGKFAVVRQYAAKFLEILHEIAVLELAKPRVINLHEVILILEYAAGGEIFSLCLPYLHQNNIVHLDLKPQNILLIVDFGMS
Ligand info
Orthosteric ligand
ATP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7Q7D, Chain A