7PCD Chain A
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Inactive — 0.1%DFG-inαC-inType1.5_Back · 70I
Resolution
1.77 Å
R-value
0.21
Predicted activity confidence0.1%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ALLRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
UniProt reference sequence
LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSR
Aligned reference sequence
LRKV----------------KVLGSGA----------------FGTVYKGIW--IPDGEN--------------------------------VKIPVAIKVLR--ENTSPKA---------------------------NKEILDEAYVMAGV--------------------------GSPYVSRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLVTQLMPY--------------GCLLDHVRE--NRG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLGSQDLLNWCMQIAKGMSYLEDV---------------------------------------------RLVHRDL-----AARNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNHVKITDFGLARLLDIDETE--YHA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGGKVPIKWMALESILR--------------------------------RRFT-HQSDVWSYGVTVWELMTF--G--------------AKPYDG--------------------------------------------------IPAREIPDLLEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDSECRPR--------------FRELVSEFSR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LRKV----------------KVLGSGA----------------FGTVYKGIW--IPDGEN--------------------------------VKIPVAIKVLR--ENTSPKA---------------------------NKEILDEAYVMAGV--------------------------GSPYVSRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLVTQLMPY--------------GCLLDHVRE--NRG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLGSQDLLNWCMQIAKGMSYLEDV---------------------------------------------RLVHRDL-----AARNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNHVKITDFGLARLLDID-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPIKWMALESILR--------------------------------RRFT-HQSDVWSYGVTVWELMTF--G--------------AKPYDG--------------------------------------------------IPAREIPDLLEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDSECRPR--------------FRELVSEFSR
Activation segment
DFGLARLLDID-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPIKWMALE
Binding pocket
KVLGSGAFGTVYKVAIKVLEILDEAYVMAGVGPYVSRLLGIQLVTQLMPYGCLLDHVREYLEDVRLVHRDLAARNVLVITDFGLA
Ligand info
Orthosteric ligand
70I
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7PCD, Chain A