7P7F Chain A
Casein kinase I isoform delta (CSNK1D)
Active — 100.0%DFG-inαC-inATPlike · AMP
Resolution
1.96 Å
R-value
0.19
Predicted activity confidence100.0%
Structure info
Alternate conformationB
Missing atoms3
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAAKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
UniProt reference sequence
YRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRN
Aligned reference sequence
YRLG----------------RKIGSGS----------------FGDIYLGTD--IA------------------------------------AGEEVAIKLEC--VKTK------------------------------HPQLHIESKIYKMM--Q-----------------------GGVGIPTIRWCGAEGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVMVMELLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFSLKTVLLLADQMISRIEYIHSK---------------------------------------------NFIHRDV-----KPDNFLMGL--GKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNLVYIIDFGLAKKYRDARTH--QHIPYREN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASINTHLG--------------------------------IEQS-RRDDLESLGYVLMYFNLG-----------------SLPWQG--LKAATKR-----------------------------------------QKYERISEKKMST--PIEVLCKGYP-----------------------------------------------------------------------------------------------------SEFATYLNFCRSLRFDDKPD--------------YSYLRQLFRN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YRLG----------------RKIGSGS----------------FGDIYLGTD--IA------------------------------------AGEEVAIKLEC--VKTK------------------------------HPQLHIESKIYKMM--Q-----------------------GGVGIPTIRWCGAEGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVMVMELLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFSLKTVLLLADQMISRIEYIHSK---------------------------------------------NFIHRDV-----KPDNFLMGL--GKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNLVYIIDFGLAKKYRDARTH--QHIPYREN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASINTHLG--------------------------------IEQS-RRDDLESLGYVLMYFNLG-----------------SLPWQG--LKAA-KR-----------------------------------------QKYERISEKKMST--PIEVLCKGYP-----------------------------------------------------------------------------------------------------SEFATYLNFCRSLRFDDKPD--------------YSYLRQLFRN
Activation segment
DFGLAKKYRDARTH--QHIPYREN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASIN
Binding pocket
RKIGSGSFGDIYLVAIKLEQLHIESKIYKMMQVGIPTIRWCVMVMELLG_PSLEDLFNFYIHSKNFIHRDVKPDNFLMIIDFGLA
Ligand info
Orthosteric ligand
AMP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7P7F, Chain A