7P1L Chain A
MAP/microtubule affinity-regulating kinase 3 (MARK3)
Inactive — 0.1%DFG-inαC-outType1 · V5E
Resolution
1.95 Å
R-value
0.211
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms50
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
QPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVSPPYAAPELDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLG
UniProt reference sequence
YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI
Aligned reference sequence
YRLL----------------KTIGKGN----------------FAKVKLARH--IL------------------------------------TGREVAIKIID--KTQLNPTS--------------------------LQKLFREVRIMKIL--------------------------NHPNIVKLFEVIETEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLYLIMEYASG--------------GEVFDYLVA--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMKEKEARSKFRQIVSAVQYCHQK---------------------------------------------RIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMNIKIADFGFSNEFTVGGKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTFCGSPPYAAPELFQG--------------------------------KKYDGPEVDVWSLGVILYTLVSG-----------------SLPFDG--------------------------------------------------QNLKELRERVLRG--KYRIPFYMS------------------------------------------------------------------------------------------------------TDCENLLKRFLVLNPIKRGT--------------LEQIMKDRWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YRLL----------------KTIGKGN----------------FAKVKLARH--IL------------------------------------TGREVAIKIID--KTQLNPTS--------------------------LQKLFREVRIMKIL--------------------------NHPNIVKLFEVIETEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLYLIMEYASG--------------GEVFDYLVA--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMKEKEARSKFRQIVSAVQYCHQK---------------------------------------------RIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMNIKIADFGFSNEFTV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPPYAAPEL--------------------------------------DGPEVDVWSLGVILYTLVSG-----------------SLPFDG--------------------------------------------------QNLKELRERVLRG--KYRIPFYMS------------------------------------------------------------------------------------------------------TDCENLLKRFLVLNPIKRGT--------------LEQIMKDRWI
Activation segment
DFGFSNEFTV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPPYAAPE
Binding pocket
KTIGKGNFAKVKLVAIKIIKLFREVRIMKILNPNIVKLFEVYLIMEYASGGEVFDYLVAYCHQKRIVHRDLKAENLLLIADFGFS
Ligand info
Orthosteric ligand
V5E
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7P1L, Chain A