7OVL Chain A
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)
Active — 59.0%DFG-outαC-inType1 · 1XZ
Resolution
2.9 Å
R-value
0.248
Predicted activity confidence59.0%
Structure info
Alternate conformationA
Missing atoms29
Missing residues5
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
QTGYLTIGGQRYQAEINDLENLGEMGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISAGCAAYMAPERIDPPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTE
UniProt reference sequence
LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI
Aligned reference sequence
LENL----------------GEMGSGT----------------CGQVWKMRF--RK------------------------------------TGHVIAVKQMR--RSGNKEE---------------------------NKRILMDLDVVLKS--H-----------------------DCPYIVQCFGTFITNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVFIAMELMG---------------TCAEKLKKR--MQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIPERILGKMTVAIVKALYYLKEK--H------------------------------------------GVIHRDV-----KPSNILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGQIKLCDFGISGRLVDSKAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRSAGCAAYMAPERIDP--PDPTK-------------------------PDYD-IRADVWSLGISLVELATG-----------------QFPYKN--C-----------------------------------------------KTDFEVLTKVLQE--EPPLLPGHMGFS---------------------------------------------------------------------------------------------------GDFQSFVKDCLTKDHRKRPK--------------YNKLLEHSFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LENL----------------GEM---------------------GQVWKMRF--RK------------------------------------TGHVIAVKQMR--RSGNKEE---------------------------NKRILMDLDVVLKS--H-----------------------DCPYIVQCFGTFITNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVFIAMELMG---------------TCAEKLKKR--MQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIPERILGKMTVAIVKALYYLKEK--H------------------------------------------GVIHRDV-----KPSNILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGQIKLCDFGI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAGCAAYMAPERIDP--------------------------------PDYD-IRADVWSLGISLVELATG-----------------QFPYKN--C-----------------------------------------------KTDFEVLTKVLQE--EPPLLPGHMGFS---------------------------------------------------------------------------------------------------GDFQSFVKDCLTKDHRKRPK--------------YNKLLEHSFI
Activation segment
DFGI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAGCAAYMAPE
Binding pocket
GEMG_____QVWKIAVKQMRILMDLDVVLKSHPYIVQCFGTFIAMELMGTCAEKLKKRMLKEKHGVIHRDVKPSNILLLCDFGIS
Ligand info
Orthosteric ligand
1XZ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7OVL, Chain A