7O7I Chain A
Homeodomain-interacting protein kinase 3 (HIPK3)
Active — 99.8%DFG-inαC-in
Resolution
2.5 Å
R-value
0.246
Predicted activity confidence99.8%
Structure info
Alternate conformation—
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICK
UniProt reference sequence
YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFV
Aligned reference sequence
YEVL----------------DFLGRGT----------------FGQVVKCWK--RG------------------------------------TNEIVAIKILK--NHPSY-----------------------------ARQGQIEVSILARL--STENA-------------------DEYNFVRAYECFQHRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTCLVFEMLE---------------QNLYDFLKQ--NKFS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPLKVIRPILQQVATALKKLKSL---------------------------------------------GLIHADL-----KPENIMLVD--PVRQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYRVKVIDFGSASHVSKTVC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STYLQSRYYRAPEIILG--------------------------------LPFC-EAIDMWSLGCVIAELFLG-----------------WPLYPG--------------------------------------------------ALEYDQIRYISQT--QGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADR------------------------------REFVSLLKKMLLIDADLRIT--------------PAETLNHPFV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEVL----------------DFLGRGT----------------FGQVVKCWK--RG------------------------------------TNEIVAIKILK--NHPSY-----------------------------ARQGQIEVSILARL--STENA-------------------DEYNFVRAYECFQHRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTCLVFEMLE---------------QNLYDFLKQ--NKFS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPLKVIRPILQQVATALKKLKSL---------------------------------------------GLIHADL-----KPENIMLVD--PVRQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYRVKVIDFGSASHVSKTVC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ST-LQSRYYRAPEIILG--------------------------------LPFC-EAIDMWSLGCVIAELFLG-----------------WPLYPG--------------------------------------------------ALEYDQIRYISQT--QGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADR------------------------------REFVSLLKKMLLIDADLRIT--------------PAETLNHPFV
Activation segment
DFGSASHVSKTVC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ST-LQSRYYRAPE
Binding pocket
DFLGRGTFGQVVKVAIKILQGQIEVSILARLSYNFVRAYECCLVFEMLE_QNLYDFLKQKLKSLGLIHADLKPENIMLVIDFGSA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7O7I, Chain A