7NZY Chain A
Casein kinase I isoform delta (CSNK1D)
Active — 99.5%DFG-inαC-inType1 · UX2
Resolution
1.85 Å
R-value
0.205
Predicted activity confidence99.5%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
RVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAAKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
UniProt reference sequence
YRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRN
Aligned reference sequence
YRLG----------------RKIGSGS----------------FGDIYLGTD--IA------------------------------------AGEEVAIKLEC--VKTK------------------------------HPQLHIESKIYKMM--Q-----------------------GGVGIPTIRWCGAEGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVMVMELLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFSLKTVLLLADQMISRIEYIHSK---------------------------------------------NFIHRDV-----KPDNFLMGL--GKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNLVYIIDFGLAKKYRDARTH--QHIPYREN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASINTHLG--------------------------------IEQS-RRDDLESLGYVLMYFNLG-----------------SLPWQG--LKAATKR-----------------------------------------QKYERISEKKMST--PIEVLCKGYP-----------------------------------------------------------------------------------------------------SEFATYLNFCRSLRFDDKPD--------------YSYLRQLFRN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YRLG----------------RKIGSGS----------------FGDIYLGTD--IA------------------------------------AGEEVAIKLEC--VKTK------------------------------HPQLHIESKIYKMM--Q-----------------------GGVGIPTIRWCGAEGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVMVMELLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFSLKTVLLLADQMISRIEYIHSK---------------------------------------------NFIHRDV-----KPDNFLMGL--GKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNLVYIIDFGLAKKYR-------QHIPYREN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASINTHLG--------------------------------IEQS-RRDDLESLGYVLMYFNLG-----------------SLPWQG--LKAA-KR-----------------------------------------QKYERISEKKMST--PIEVLCKGYP-----------------------------------------------------------------------------------------------------SEFATYLNFCRSLRFDDKPD--------------YSYLRQLFRN
Activation segment
DFGLAKKYR-------QHIPYREN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASIN
Binding pocket
RKIGSGSFGDIYLVAIKLEQLHIESKIYKMMQVGIPTIRWCVMVMELLG_PSLEDLFNFYIHSKNFIHRDVKPDNFLMIIDFGLA
Ligand info
Orthosteric ligand
UX2
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7NZY, Chain A