7NTH Chain A
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)
Inactive — 0.0%DFG-outαC-inType1 · URW
Resolution
1.97 Å
R-value
0.182
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues7
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GSLHMIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQHSLPPGEDGRVEPYVDFAEFYRLWSVDHG
UniProt reference sequence
IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTH
Aligned reference sequence
IEVE----------------EVVGRGA----------------FGVVCKAKW----------------------------------------RAKDVAIKQIE--SESE------------------------------RKAFIVELRQLSRV--------------------------NHPNIVKLYGACLN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVCLVMEYAEG--------------GSLYNVLHG--AEPLP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYTAAHAMSWCLQCSQGVAYLHSM--QPK----------------------------------------ALIHRDL-----KPPNLLLVA--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVLKICDFGTACDIQTHM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNNKGSAAWMAPEVFEG--------------------------------SNYS-EKCDVFSWGIILWEVITR-----------------RKPFDE--IG----------------------------------------------GPAFRIMWAVHNG--TRPPLIKNLP-----------------------------------------------------------------------------------------------------KPIESLMTRCWSKDPSQRPS--------------MEEIVKIMTH
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IEVE----------------EVVGRGA----------------FGVVCKAKW----------------------------------------RAKDVAIKQIE--SESE------------------------------RKAFIVELRQLSRV--------------------------NHPNIVKLYGACLN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVCLVMEYAEG--------------GSLYNVLHG--AEPLP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYTAAHAMSWCLQCSQGVAYLHSM--QPK----------------------------------------ALIHRDL-----KPPNLLLVA--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVLKICDFGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSAAWMAPEVFEG--------------------------------SNYS-EKCDVFSWGIILWEVITR-----------------RKPFDE--IG----------------------------------------------GPAFRIMWAVHNG--TRPPLIKNLP-----------------------------------------------------------------------------------------------------KPIESLMTRCWSKDPSQRPS--------------MEEIVKIMTH
Activation segment
DFGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSAAWMAPE
Binding pocket
EVVGRGAFGVVCKVAIKQIAFIVELRQLSRVNPNIVKLYGACLVMEYAEGGSLYNVLHGSMQPKALIHRDLKPPNLLL_______
Ligand info
Orthosteric ligand
URW
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7NTH, Chain A