7NH5 Chain A
RAC-alpha serine/threonine-protein kinase (AKT1)
Inactive — 1.5%DFG-outαC-outAllosteric · UC8
Resolution
1.9 Å
R-value
0.201
Predicted activity confidence1.5%
Structure info
Alternate conformationB
Missing atoms4
Missing residues10
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
DVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDEAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVINSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTA
UniProt reference sequence
FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF
Aligned reference sequence
FEYL----------------KLLGKGT----------------FGKVILVKE--KA------------------------------------TGRYYAMKILK--KEVIVAKDE-------------------------VAHTLTENRVLQNS--------------------------RHPFLTALKYSFQTHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLCFVMEYANG--------------GELFFHLSR--ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSEDRARFYGAEIVSALDYLHSE--K------------------------------------------NVVYRDL-----KLENLMLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKITDFGLCKEGIKDGAT--M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTFCGTPEYLAPEVLED--------------------------------NDYG-RAVDWWGLGVVMYEMMCG-----------------RLPFYN--------------------------------------------------QDHEKLFELILME--EIRFPRTLG------------------------------------------------------------------------------------------------------PEAKSLLSGLLKKDPKQRLG--GGSED-------AKEIMQHRFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEYL----------------KLLGKGT----------------FGKVILVKE--KA------------------------------------TGRYYAMKILK--KEVI------------------------------------------NS--------------------------RHPFLTALKYSFQTHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLCFVMEYANG--------------GELFFHLSR--ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSEDRARFYGAEIVSALDYLHSE--K------------------------------------------NVVYRDL-----KLENLMLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKITDFGLCKEGIK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FCGTPEYLAPEVLED--------------------------------NDYG-RAVDWWGLGVVMYEMMCG-----------------RLPFYN--------------------------------------------------QDHEKLFELILME--EIRFPRTLG------------------------------------------------------------------------------------------------------PEAKSLLSGLLKKDPKQRLG--GGSED-------AKEIMQHRFF
Activation segment
DFGLCKEGIK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FCGTPEYLAPE
Binding pocket
KLLGKGTFGKVILYAMKIL__________NSRPFLTALKYSCFVMEYANGGELFFHLSRLHSEKNVVYRDLKLENLMLITDFGLC
Ligand info
Orthosteric ligand
UC8
Allosteric ligand
None
Ligand typeAllosteric
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7NH5, Chain A