7N3U Chain A
Wee1-like protein kinase (WEE1)
Inactive — 37.9%DFG-inαC-inType1 · 05J
Resolution
2.65 Å
R-value
0.22
Predicted activity confidence37.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLL
UniProt reference sequence
FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL
Aligned reference sequence
FHEL----------------EKIGSGE----------------FGSVFKCVK--RL------------------------------------DGCIYAIKRSK--KPLAGSVD--------------------------EQNALREVYAHAVL--G-----------------------QHSHVVRYFSAWAEDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMLIQNEYCNG--------------GSLADAISE--NYRIMS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YFKEAELKDLLLQVGRGLRYIHSM---------------------------------------------SLVHMDI-----KPSNIFISR--TSIPNAASEEGDEDDWASN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVMFKIGDLGHVTRISSP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVEEGDSRFLANEVLQE--N-----------------------------YTHL-PKADIFALALTVVCAAGA-------------------------EPL---------------------------------------------PRNGDQWHEIRQG--RLPRIPQVLS-----------------------------------------------------------------------------------------------------QEFTELLKVMIHPDPERRPS--------------AMALVKHSVL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FHEL----------------EKIGSGE----------------FGSVFKCVK--RL------------------------------------DGCIYAIKRSK--KPLAGSVD--------------------------EQNALREVYAHAVL--G-----------------------QHSHVVRYFSAWAEDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMLIQNEYCNG--------------GSLADAISE--NYRIMS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YFKEAELKDLLLQVGRGLRYIHSM---------------------------------------------SLVHMDI-----KPSNIFISR--T-----------------N-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVMFKIGDLGHVTRISSP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVEEGDSRFLANEVLQE--N-----------------------------YTHL-PKADIFALALTVVCAAGA-------------------------EPL---------------------------------------------PRNGDQWHEIRQG--RLPRIPQVLS-----------------------------------------------------------------------------------------------------QEFTELLKVMIHPDPERRPS--------------AMALVKHSVL
Activation segment
DLGHVTRISSP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVEEGDSRFLANE
Binding pocket
EKIGSGEFGSVFKYAIKRSNALREVYAHAVLGSHVVRYFSALIQNEYCNGGSLADAISEYIHSMSLVHMDIKPSNIFIIGDLGHV
Ligand info
Orthosteric ligand
05J
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7N3U, Chain A