7MYJ Chain A
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)
Active — 99.8%DFG-outαC-inType1,Allosteric · 4O7
Resolution
2.95 Å
R-value
0.215
Predicted activity confidence99.8%
Structure info
Alternate conformation—
Missing atoms27
Missing residues7
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQGLPSYLFPEDPSYDANVIDDEAVESEVMNSLYAYHLIIDNRRIMNQASEFYLASSPPGLKPHPERMPPLIVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEPRLGSHTMDFFEMCASLITTLA
UniProt reference sequence
YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF
Aligned reference sequence
YVLG----------------DTLGVGT----------------FGKVKIGEH--QL------------------------------------TGHKVAVKILN--RQKIRSLDV-------------------------VGKIKREIQNLKLF--------------------------RHPHIIKLYQVISTPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFFMVMEYVSG--------------GELFDYICK--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVEEMEARRLFQQILSAVDYCHRH---------------------------------------------MVVHRDL-----KPENVLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMNAKIADFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSCGSPNYAAPEVISG--------------------------------RLYAGPEVDIWSCGVILYALLCG-----------------TLPFDD--------------------------------------------------EHVPTLFKKIRGG--VFYIPEYLN------------------------------------------------------------------------------------------------------RSVATLLMHMLQVDPLKRAT--------------IKDIREHEWF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YVLG----------------DTLGVGT----------------FGKVKIGEH--QL------------------------------------TGHKVAVKILN--RQKIRSLDV-------------------------VGKIKREIQNLKLF--------------------------RHPHIIKLYQVISTPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFFMVMEYVSG--------------GELFDYICK--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVEEMEARRLFQQILSAVDYCHRH---------------------------------------------MVVHRDL-----KPENVLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMNAKIADFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-SCGSPNYAAPEVISG--------------------------------RLYAGPEVDIWSCGVILYALLCG-----------------TLPFDD--------------------------------------------------EHVPTLFKKIRGG--VFYIPEYLN------------------------------------------------------------------------------------------------------RSVATLLMHMLQVDPLKRAT--------------IKDIREHEWF
Activation segment
DFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-SCGSPNYAAPE
Binding pocket
DTLGVGTFGKVKIVAVKILKIKREIQNLKLFRPHIIKLYQVFMVMEYVSGGELFDYICKYCHRHMVVHRDLKPENVLL_______
Ligand info
Orthosteric ligand
4O7
Allosteric ligand
ZQV
Ligand typeType1,Allosteric
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7MYJ, Chain A