7MX3 Chain A
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
Active — 99.5%DFG-inαC-inType1.5_Back · ZOV
Resolution
3.23 Å
R-value
0.244
Predicted activity confidence99.5%
Structure info
Alternate conformation—
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PAPLVSIEELENQELVGKGGGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQAPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRR
UniProt reference sequence
LENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDE
Aligned reference sequence
LENQ----------------ELVGKGG----------------FGTVFRAQH--RK------------------------------------WGYDVAVKIVN------------------------------------SKAISREVKAMASL--------------------------DNEFVLRLEGVIEKVN--WDQDP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPALVTKFMEN--------------GSLSGLLQS--QC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRPWPLLCRLLKEVVLGMFYLHDQ--NP-----------------------------------------VLLHRDL-----KPSNVLLDP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELHVKLADFGLSTFQGGSQSG--TGS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEPGGTLGYLAPELFVN--VN----------------------------RKAS-TASDVYSFGILMWAVLAG-------------------------REVELP------------------------------------------TEPSLVYEAVCNR--QNRPSLAELPQAGPETPGL--------------------------------------------------------------------------------------------EGLKELMQLCWSSEPKDRPS--------------FQECLPKTDE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LENQ----------------ELVGKGG-----------------GTVFRAQH--RK------------------------------------WGYDVAVKIVN------------------------------------SKAISREVKAMASL--------------------------DNEFVLRLEGVIEKVN--WDQDP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPALVTKFMEN--------------GSLSGLLQS--QA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRPWPLLCRLLKEVVLGMFYLHDQ--NP-----------------------------------------VLLHRDL-----KPSNVLLDP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELHVKLADFGLSTFQGGSQS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGYLAPELFVN--VN----------------------------RKAS-TASDVYSFGILMWAVLAG-------------------------REVELP------------------------------------------TEPSLVYEAVCNR--QNRPSLAELPQAGPETPGL--------------------------------------------------------------------------------------------EGLKELMQLCWSSEPKDRPS--------------FQECLPKTDE
Activation segment
DFGLSTFQGGSQS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGYLAPE
Binding pocket
ELVGKGG_GTVFRVAVKIVAISREVKAMASLDEFVLRLEGVALVTKFMENGSLSGLLQSHDQNPVLLHRDLKPSNVLLLADFGLS
Ligand info
Orthosteric ligand
ZOV
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7MX3, Chain A