7MON Chain B
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
Inactive — 0.1%DFG-inαC-outType1.5_Front · ZL1
Resolution
2.23 Å
R-value
0.212
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues6
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
KLWPSGAPAPLVSIEELENQELVGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDPKPALVTKFMENGSLSGLLQSQAPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSGEPGGTLGYLAPELFVNKASTASDVYSFGILMWAVLAGREVELPEPLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSS
UniProt reference sequence
LENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDE
Aligned reference sequence
LENQ----------------ELVGKGG----------------FGTVFRAQH--RK------------------------------------WGYDVAVKIVN------------------------------------SKAISREVKAMASL--------------------------DNEFVLRLEGVIEKVN--WDQDP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPALVTKFMEN--------------GSLSGLLQS--QC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRPWPLLCRLLKEVVLGMFYLHDQ--NP-----------------------------------------VLLHRDL-----KPSNVLLDP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELHVKLADFGLSTFQGGSQSG--TGS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEPGGTLGYLAPELFVN--VN----------------------------RKAS-TASDVYSFGILMWAVLAG-------------------------REVELP------------------------------------------TEPSLVYEAVCNR--QNRPSLAELPQAGPETPGL--------------------------------------------------------------------------------------------EGLKELMQLCWSSEPKDRPS--------------FQECLPKTDE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LENQ----------------ELV---------------------GTVFRAQH--RK------------------------------------WGYDVAVKIVN------------------------------------SKAISREVKAMASL--------------------------DNEFVLRLEGVIEKVN--W--DP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPALVTKFMEN--------------GSLSGLLQS--QA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRPWPLLCRLLKEVVLGMFYLHDQ--NP-----------------------------------------VLLHRDL-----KPSNVLLDP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELHVKLADFGL--------------S-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEPGGTLGYLAPELFVN---------------------------------KAS-TASDVYSFGILMWAVLAG-------------------------REVELP-------------------------------------------EP-LVYEAVCNR--QNRPSLAELPQAGPETPGL--------------------------------------------------------------------------------------------EGLKELMQLCWSSEPKDRPS--------------FQECLPKTDE
Activation segment
DFGL--------------S-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEPGGTLGYLAPE
Binding pocket
ELV_____GTVFRVAVKIVAISREVKAMASLDEFVLRLEGVALVTKFMENGSLSGLLQSHDQNPVLLHRDLKPSNVLLLADFGL_
Ligand info
Orthosteric ligand
ZL1
Allosteric ligand
None
Ligand typeType1.5_Front
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7MON, Chain B