7MGK Chain A
Serine/threonine-protein kinase TNNI3K (TNNI3K)
Inactive — 11.2%DFG-outαC-inType2 · ZGD
Resolution
3.1 Å
R-value
0.198
Predicted activity confidence11.2%
Structure info
Alternate conformationB
Missing atoms15
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGEGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNI
UniProt reference sequence
IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE
Aligned reference sequence
IEFH----------------EIIGSGS----------------FGKVYKGRC----------------------------------------RNKIVAIKRYR--ANTYCSKSD-------------------------VDMFCREVSILCQL--------------------------NHPCVIQFVGACLNDP--S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFAIVTQYISG--------------GSLFSLLHE--QKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILDLQSKLIIAVDVAKGMEYLHNL--TQ-----------------------------------------PIIHRDL-----NSHNILLYE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHAVVADFGESRFLQSLDED--NM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKQPGNLRWMAPEVFTQ--C-----------------------------TRYT-IKADVFSYALCLWEILTG-----------------EIPFAH--------------------------------------------------LKPAAAAADMAYH--HIRPPIGYSIP----------------------------------------------------------------------------------------------------KPISSLLIRGWNACPEGRPE--------------FSEVVMKLEE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IEFH----------------EIIGSGS----------------FGKVYKGRC----------------------------------------RNKIVAIKRYR-------SKSD-------------------------VDMFCREVSILCQL--------------------------NHPCVIQFVGACLNDP--S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFAIVTQYISG--------------GSLFSLLHE--QKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILDLQSKLIIAVDVAKGMEYLHNL--TQ-----------------------------------------PIIHRDL-----NSHNILLYE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHAVVADFGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNLRWMAPEVFTQ--C-----------------------------TRYT-IKADVFSYALCLWEILTG-----------------EIPFAH--------------------------------------------------LKPAAAAADMAYH--HIRPPIGYSIP----------------------------------------------------------------------------------------------------KPISSLLIRGWNACPEGRPE--------------FSEVVMKLEE
Activation segment
DFGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNLRWMAPE
Binding pocket
EIIGSGSFGKVYKVAIKRYMFCREVSILCQLNPCVIQFVGAAIVTQYISGGSLFSLLHEHNLTQPIIHRDLNSHNILLVADFGE_
Ligand info
Orthosteric ligand
ZGD
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7MGK, Chain A