7MFC Chain A
Macrophage colony-stimulating factor 1 receptor (CSF1R)
Inactive — 0.1%DFG-outαC-inType2 · Z6V
Resolution
2.8 Å
R-value
0.229
Predicted activity confidence0.1%
Structure info
Alternate conformationA
Missing atoms26
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
TQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQITSFLQEQ
UniProt reference sequence
LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE
Aligned reference sequence
LQFG----------------KTLGAGA----------------FGKVVEATA--FGLGKED-------------------------------AVLKVAVKMLK--STAHADE---------------------------KEALMSELKIMSHL--G-----------------------QHENIVNLLGACTHGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVLVITEYCCY--------------GDLLNFLRR--KAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLELRDLLHFSSQVAQGMAFLASK---------------------------------------------NCIHRDV-----AARNVLLTN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHVAKIGDFGLARDIMNDSNY--IVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESIFD--------------------------------CVYT-VQSDVWSYGILLWEIFSL--G--------------LNPYPG--I-----------------------------------------------LVNSKFYKLVKDG--YQMAQPAFAP-----------------------------------------------------------------------------------------------------KNIYSIMQACWALEPTHRPT--------------FQQICSFLQE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LQFG----------------KTLGAGA----------------FGKVVEATA--FGLGKED-------------------------------AVLKVAVKMLK--STAHADE---------------------------KEALMSELKIMSHL--G-----------------------QHENIVNLLGACTHGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVLVITEYCTY--------------GDLLNFLRR--KAEAMLGPSL------------------------------------------------------------R----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLELRDLLHFSSQVAQGMAFLASK---------------------------------------------NCIHRDV-----AARNVLLTN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHVAKIGDFGLARDIMNDSNY--IVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESIFD--------------------------------SVYT-VQSDVWSYGILLWEIFSL--G--------------LNPYPG--I-----------------------------------------------LVNSKFYKLVKDG--YQMAQPAFAP-----------------------------------------------------------------------------------------------------KNIYSIMQACWALEPTHRPT--------------FQQITSFLQE
Activation segment
DFGLARDIMNDSNY--IVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPE
Binding pocket
KTLGAGAFGKVVEVAVKMLALMSELKIMSHLGENIVNLLGALVITEYCTYGDLLNFLRRFLASKNCIHRDVAARNVLLIGDFGLA
Ligand info
Orthosteric ligand
Z6V
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7MFC, Chain A