7M74 Chain A
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
Inactive — 0.0%DFG-outαC-outType1 · TAK
Resolution
3.93 Å
R-value
999.0
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues7
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDELTPRPGSHTIEFFEMCANLIKILAQ
UniProt reference sequence
YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF
Aligned reference sequence
YILG----------------DTLGVGT----------------FGKVKVGKH--EL------------------------------------TGHKVAVKILN--RQKIRSLDV-------------------------VGKIRREIQNLKLF--------------------------RHPHIIKLYQVISTPS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIFMVMEYVSG--------------GELFDYICK--NG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLDEKESRRLFQQILSGVDYCHRH---------------------------------------------MVVHRDL-----KPENVLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMNAKIADFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSCGSPNYAAPEVISG--------------------------------RLYAGPEVDIWSSGVILYALLCG-----------------TLPFDD--------------------------------------------------DHVPTLFKKICDG--IFYTPQYLN------------------------------------------------------------------------------------------------------PSVISLLKHMLQVDPMKRAT--------------IKDIREHEWF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YILG----------------DTLGVGT----------------FGKVKVGKH--EL------------------------------------TGHKVAVKILN--RQKIRSLDV-------------------------VGKIRREIQNLKLF--------------------------RHPHIIKLYQVISTPS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIFMVMEYVSG--------------GELFDYICK--NG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLDEKESRRLFQQILSGVDYCHRH---------------------------------------------MVVHRDL-----KPENVLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMNAKIADFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSCGSPNYAAPEVISG--------------------------------RLYAGPEVDIWSSGVILYALLCG-----------------TLPFDD--------------------------------------------------DHVPTLFKKICDG--IFYTPQYLN------------------------------------------------------------------------------------------------------PSVISLLKHMLQVDPMKRAT--------------IKDIREHEWF
Activation segment
DFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSCGSPNYAAPE
Binding pocket
DTLGVGTFGKVKVVAVKILKIRREIQNLKLFRPHIIKLYQVFMVMEYVSGGELFDYICKYCHRHMVVHRDLKPENVLL_______
Ligand info
Orthosteric ligand
TAK
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7M74, Chain A