7LVH Chain A
AP2-associated protein kinase 1 (AAK1)
Active — 96.9%DFG-inαC-inType1 · YFS
Resolution
2.65 Å
R-value
0.267
Predicted activity confidence96.9%
Structure info
Alternate conformation—
Missing atoms58
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
YIGRVFGIGRQQVTVDEVLAEGGFALVFLVRTSNGVKCALKRMFVNNEHDLQVCKREIQIMRDLGHKNIVGYIDSSINNVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCTPIIHRDLKVENILLHGHYVLCDFGSATNKFQNPEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGSFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPVPNVQNSP
UniProt reference sequence
VTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFK
Aligned reference sequence
VTVD----------------EVLAEGG----------------FAIVFLVRT--S-------------------------------------NGMKCALKRMF--VNNEHD----------------------------LQVCKREIQIMRDL--S-----------------------GHKNIVGYIDSSINNV--SSGDVW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVLILMDFCRG--------------GQVVNLMNQ--RLQT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFTENEVLQIFCDTCEAVARLHQC--KT-----------------------------------------PIIHRDL-----KVENILLHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGHYVLCDFGSATNKFQNPQT--EGVNAVEDE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKKYTTLSYRAPEMVNL--YSG---------------------------KIIT-TKADIWALGCLLYKLCYF-----------------TLPFGE-------------------------------------------------------SQVAICDG--NFTIPDNSRYS----------------------------------------------------------------------------------------------------QDMHCLIRYMLEPDPDKRPD--------------IYQVSYFSFK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VTVD----------------EVLAEGG----------------FALVFLVRT--S-------------------------------------NGVKCALKRMF--VNNEHD----------------------------LQVCKREIQIMRDL--------------------------GHKNIVGYIDSSINN-------VW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVLILMDFCRG--------------GQVVNLMNQ--RLQT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFTENEVLQIFCDTCEAVARLHQC---T-----------------------------------------PIIHRDL-----KVENILLH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHYVLCDFGSATNKFQNP----EGVNAVEDE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKKYTTLSYRAPEMVNL--YSG---------------------------KIIT-TKADIWALGCLLYKLCYF-----------------TLPFGE-------------------------------------------------------SQVAICDG--SFTIPDNSRYS----------------------------------------------------------------------------------------------------QDMHCLIRYMLEPDPDKRPD--------------IYQVSYFSFK
Activation segment
DFGSATNKFQNP----EGVNAVEDE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKKYTTLSYRAPE
Binding pocket
EVLAEGGFALVFLCALKRMVCKREIQIMRDL_KNIVGYIDSLILMDFCRGGQVVNLMNQHQC_TPIIHRDLKVENILLLCDFGSA
Ligand info
Orthosteric ligand
YFS
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7LVH, Chain A