7L24 Chain C
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)
Inactive — 0.0%DFG-inαC-inType1 · XHV
Resolution
2.68 Å
R-value
0.227
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
IFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGAARRLAFITPYWMAPEVAAVALKGCYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKN
UniProt reference sequence
YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV
Aligned reference sequence
YDLL----------------QRLGGGT----------------YGEVFKARD--KV------------------------------------SGDLVALKMVK--MEPDDD----------------------------VSTLQKEILILKTC--------------------------RHANIVAYHGSYLWLQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWICMEFCGA--------------GSLQDIYQV--TG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSELQISYVCREVLQGLAYLHSQ---------------------------------------------KKIHRDI-----KGANILIND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGEVRLADFGISAQIGATLAR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSFIGTPYWMAPEVAAV--ALK---------------------------GGYN-ELCDIWSLGITAIELAEL-----------------QPPLFD--------------------------------------------------VHPLRVLFLMTKS--GYQPPRLKEKGKWS-------------------------------------------------------------------------------------------------AAFHNFIKVTLTKSPKKRPS--------------ATKMLSHQLV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YDLL----------------QRLGGGT----------------YGEVFKARD--KV------------------------------------SGDLVALKMVK--MEPDDD----------------------------VSTLQKEILILKTC--------------------------RHANIVAYHGSYLWLQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWICMEFCGA--------------GSLQDIYQV--TG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSELQISYVCREVLQGLAYLHSQ---------------------------------------------KKIHRDI-----KGANILIND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGEVRLADFGISAQIGA--AR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAFI-TPYWMAPEVAAV--ALK---------------------------GCYN-ELCDIWSLGITAIELAEL-----------------QPPLFD--------------------------------------------------VHPLRVLFLMTKS--GYQPPRLKEKGKWS-------------------------------------------------------------------------------------------------AAFHNFIKVTLTKSPKKRPS--------------ATKMLSHQLV
Activation segment
DFGISAQIGA--AR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAFI-TPYWMAPE
Binding pocket
QRLGGGTYGEVFKVALKMVTLQKEILILKTCRANIVAYHGSWICMEFCGAGSLQDIYQVYLHSQKKIHRDIKGANILILADFGIS
Ligand info
Orthosteric ligand
XHV
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7L24, Chain C