7KXW Chain A
Serine/threonine-protein kinase DCLK1 (DCLK1)
Active — 97.9%DFG-inαC-inType1 · XBD
Resolution
3.002 Å
R-value
0.203
Predicted activity confidence97.9%
Structure info
Alternate conformation—
Missing atoms8
Missing residues5
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
IPATITERYKVGRTIAVVKECVERSTAREYALKIIKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVN
UniProt reference sequence
YKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWV
Aligned reference sequence
YKVG----------------RTIGDGN----------------FAVVKECVE--RS------------------------------------TAREYALKIIK--KSKCRGK---------------------------EHMIQNEVSILRRV--------------------------KHPNIVLLIEEMDVPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELYLVMELVKG--------------GDLFDAITS--TN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYTERDASGMLYNLASAIKYLHSL---------------------------------------------NIVHRDI-----KPENLLVYE--HQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSLKLGDFGLATIVDGPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTVCGTPTYVAPEIIAE--------------------------------TGYG-LKVDIWAAGVITYILLCG-----------------FPPFRG--SG----------------------------------------------DDQEVLFDQILMG--QVDFPSPYWDNVS--------------------------------------------------------------------------------------------------DSAKELITMMLLVDVDQRFS--------------AVQVLEHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YKVG----------------RTI---------------------AVVKECVE--RS------------------------------------TAREYALKII---------K---------------------------EHMIQNEVSILRRV--------------------------KHPNIVLLIEEMDVPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELYLVMELVKG--------------GDLFDAITS--TN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KY-ERDASGMLYNLASAIKYLHSL---------------------------------------------NIVHRDI-----KPENLLVYE--H-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLKLGDFGLATIVDGPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTVCGTPTYVAPEIIAE--------------------------------TGYG-LKVDIWAAGVITYILLCG-----------------FPPFRG--S-------------------------------------------------QEVLFDQILMG--QVDFPSPYWDNVS--------------------------------------------------------------------------------------------------DSAKELITMMLLVDVDQRFS--------------AVQVLEHPWV
Activation segment
DFGLATIVDGPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTVCGTPTYVAPE
Binding pocket
RTI_____AVVKEYALKIIMIQNEVSILRRVKPNIVLLIEEYLVMELVKGGDLFDAITSYLHSLNIVHRDIKPENLLVLGDFGLA
Ligand info
Orthosteric ligand
XBD
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7KXW, Chain A