7KX6 Chain A
Serine/threonine-protein kinase DCLK1 (DCLK1)
Active — 98.6%DFG-inαC-inType1 · X7Y
Resolution
2.5 Å
R-value
0.194
Predicted activity confidence98.6%
Structure info
Alternate conformation—
Missing atoms19
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
QIPATITERYKVGRTIGDFAVVKECVERSTAREYALKIIKKSKHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVN
UniProt reference sequence
YKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWV
Aligned reference sequence
YKVG----------------RTIGDGN----------------FAVVKECVE--RS------------------------------------TAREYALKIIK--KSKCRGK---------------------------EHMIQNEVSILRRV--------------------------KHPNIVLLIEEMDVPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELYLVMELVKG--------------GDLFDAITS--TN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYTERDASGMLYNLASAIKYLHSL---------------------------------------------NIVHRDI-----KPENLLVYE--HQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSLKLGDFGLATIVDGPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTVCGTPTYVAPEIIAE--------------------------------TGYG-LKVDIWAAGVITYILLCG-----------------FPPFRG--SG----------------------------------------------DDQEVLFDQILMG--QVDFPSPYWDNVS--------------------------------------------------------------------------------------------------DSAKELITMMLLVDVDQRFS--------------AVQVLEHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YKVG----------------RTIGD------------------FAVVKECVE--RS------------------------------------TAREYALKIIK--KSK--------------------------------HMIQNEVSILRRV--------------------------KHPNIVLLIEEMDVPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELYLVMELVKG--------------GDLFDAITS--TN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYTERDASGMLYNLASAIKYLHSL---------------------------------------------NIVHRDI-----KPENLLVYE--HQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSLKLGDFGLATIVDGPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTVCGTPTYVAPEIIAE--------------------------------TGYG-LKVDIWAAGVITYILLCG-----------------FPPFRG--S-------------------------------------------------QEVLFDQILMG--QVDFPSPYWDNVS--------------------------------------------------------------------------------------------------DSAKELITMMLLVDVDQRFS--------------AVQVLEHPWV
Activation segment
DFGLATIVDGPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTVCGTPTYVAPE
Binding pocket
RTIGD__FAVVKEYALKIIMIQNEVSILRRVKPNIVLLIEEYLVMELVKGGDLFDAITSYLHSLNIVHRDIKPENLLVLGDFGLA
Ligand info
Orthosteric ligand
X7Y
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7KX6, Chain A