7KJB Chain A
Ephrin type-A receptor 2 (EPHA2)
Active — 64.5%DFG-inαC-in
Resolution
2.8 Å
R-value
0.2
Predicted activity confidence64.5%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPETSVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGL
UniProt reference sequence
VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDK
Aligned reference sequence
VTRQ----------------KVIGAGE----------------FGEVYKGML--KTSSGK--------------------------------KEVPVAIKTLK--AGYTEKQ---------------------------RVDFLGEAGIMGQF--------------------------SHHNIIRLEGVISKYK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMMIITEYMEN--------------GALDKFLRE--KDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFSVLQLVGMLRGIAAGMKYLANM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVLEDDPEA--TYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGGKIPIRWTAPEAISY--------------------------------RKFT-SASDVWSFGIVMWEVMTY--G--------------ERPYWE--------------------------------------------------LSNHEVMKAINDG--FRLPTPMDCP-----------------------------------------------------------------------------------------------------SAIYQLMMQCWQQERARRPK--------------FADIVSILDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VTRQ----------------KVIGAGE----------------FGEVYKGML-------K--------------------------------KEVPVAIKTLK--AGYTEKQ---------------------------RVDFLGEAGIMGQF--------------------------SHHNIIRLEGVISKYK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMMIITEYMEN--------------GALDKFLRE--KDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFSVLQLVGMLRGIAAGMKYLANM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVLEDDPEA--TYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGGKIPIRWTAPEAISY--------------------------------RKFT-SASDVWSFGIVMWEVMTY--G--------------ERPYWE--------------------------------------------------LSNHEVMKAINDG--FRLPTPMDCP-----------------------------------------------------------------------------------------------------SAIYQLMMQCWQQERARRPK--------------FADIVSILDK
Activation segment
DFGLSRVLEDDPEA--TYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGGKIPIRWTAPE
Binding pocket
KVIGAGEFGEVYKVAIKTLDFLGEAGIMGQFSHNIIRLEGVMIITEYMENGALDKFLREYLANMNYVHRDLAARNILVVSDFGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7KJB, Chain A