7KJA Chain A
Ephrin type-A receptor 2 (EPHA2)
Inactive — 0.0%DFG-inαC-inATPlike · ACP
Resolution
1.75 Å
R-value
0.19
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GPGDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI
UniProt reference sequence
VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDK
Aligned reference sequence
VTRQ----------------KVIGAGE----------------FGEVYKGML--KTSSGK--------------------------------KEVPVAIKTLK--AGYTEKQ---------------------------RVDFLGEAGIMGQF--------------------------SHHNIIRLEGVISKYK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMMIITEYMEN--------------GALDKFLRE--KDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFSVLQLVGMLRGIAAGMKYLANM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVLEDDPEA--TYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGGKIPIRWTAPEAISY--------------------------------RKFT-SASDVWSFGIVMWEVMTY--G--------------ERPYWE--------------------------------------------------LSNHEVMKAINDG--FRLPTPMDCP-----------------------------------------------------------------------------------------------------SAIYQLMMQCWQQERARRPK--------------FADIVSILDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VTRQ----------------KVIGAGE----------------FGEVYKGML--KTSSGK--------------------------------KEVPVAIKTLK--AGYTEKQ---------------------------RVDFLGEAGIMGQF--------------------------SHHNIIRLEGVISKYK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMMIITEYMEN--------------GALDKFLRE--KDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFSVLQLVGMLRGIAAGMKYLANM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTAPEAISY--------------------------------RKFT-SASDVWSFGIVMWEVMTY--G--------------ERPYWE--------------------------------------------------LSNHEVMKAINDG--FRLPTPMDCP-----------------------------------------------------------------------------------------------------SAIYQLMMQCWQQERARRPK--------------FADIVSILDK
Activation segment
DFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTAPE
Binding pocket
KVIGAGEFGEVYKVAIKTLDFLGEAGIMGQFSHNIIRLEGVMIITEYMENGALDKFLREYLANMNYVHRDLAARNILVVSDFG__
Ligand info
Orthosteric ligand
ACP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7KJA, Chain A