7KAC Chain A
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)
Inactive — 23.2%DFG-inαC-outType1 · W9D
Resolution
1.85 Å
R-value
0.217
Predicted activity confidence23.2%
Structure info
Alternate conformation—
Missing atoms57
Missing residues3
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPDRVLELMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIE
UniProt reference sequence
YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV
Aligned reference sequence
YDLL----------------QRLGGGT----------------YGEVFKARD--KV------------------------------------SGDLVALKMVK--MEPDDD----------------------------VSTLQKEILILKTC--------------------------RHANIVAYHGSYLWLQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWICMEFCGA--------------GSLQDIYQV--TG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSELQISYVCREVLQGLAYLHSQ---------------------------------------------KKIHRDI-----KGANILIND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGEVRLADFGISAQIGATLAR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSFIGTPYWMAPEVAAV--ALK---------------------------GGYN-ELCDIWSLGITAIELAEL-----------------QPPLFD--------------------------------------------------VHPLRVLFLMTKS--GYQPPRLKEKGKWS-------------------------------------------------------------------------------------------------AAFHNFIKVTLTKSPKKRPS--------------ATKMLSHQLV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YDLL----------------QRLGGGT----------------YGEVFKARD--KV------------------------------------SGDLVALKMVK--MEPDDD----------------------------VSTLQKEILILKTC--------------------------RHANIVAYHGSYLWLQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWICMEFCGA--------------GSLQDIYQV--TG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSELQISYVCREVLQGLAYLHSQ---------------------------------------------KKIHRDI-----KGANILIND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGEVRLADF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FIGTPYWMAPEVAAV--ALK---------------------------GGYN-ELCDIWSLGITAIELAEL-----------------QPPLFD--------------------------------------------------VHPDRVLELMTKS--GYQPPRLKEKGKWS-------------------------------------------------------------------------------------------------AAFHNFIKVTLTKSPKKRPS--------------ATKMLSHQLV
Activation segment
DF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FIGTPYWMAPE
Binding pocket
QRLGGGTYGEVFKVALKMVTLQKEILILKTCRANIVAYHGSWICMEFCGAGSLQDIYQVYLHSQKKIHRDIKGANILILADF___
Ligand info
Orthosteric ligand
W9D
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7KAC, Chain A