7K0V Chain A
Serine/threonine-protein kinase B-raf (BRAF)
Inactive — 0.8%DFG-outαC-inType2 · VQP
Resolution
1.93 Å
R-value
0.187
Predicted activity confidence0.8%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYKHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATQFEQLSGSILWMAPEVIRMNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARELS
UniProt reference sequence
ITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIEL
Aligned reference sequence
ITVG----------------QRIGSGS----------------FGTVYKGKW-----------------------------------------HGDVAVKMLN--VTAPTPQQ--------------------------LQAFKNEVGVLRKT--------------------------RHVNILLFMGYSTKP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLAIVTQWCEG--------------SSLYHHLHI--IET------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFEMIKLIDIARQTAQGMDYLHAK---------------------------------------------SIIHRDL-----KSNNIFLHE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTVKIGDFGLATVKSRWSGS--HQF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQLSGSILWMAPEVIRM--QDK---------------------------NPYS-FQSDVYAFGIVLYELMTG-----------------QLPYSN--I-----------------------------------------------NNRDQIIFMVGRG--YLSPDLSKVRSNCP-------------------------------------------------------------------------------------------------KAMKRLMAECLKKKRDERPL--------------FPQILASIEL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITVG----------------QRIGSGS----------------FGTVYKGKW-----------------------------------------HGDVAVKMLN--VTAPTPQQ--------------------------LQAFKNEVGVLRKT--------------------------RHVNILLFMGYSTKP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLAIVTQWCEG--------------SSLYKHLHA--SET------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFEMKKLIDIARQTARGMDYLHAK---------------------------------------------SIIHRDL-----KSNNIFLHE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNTVKIGDFGLAT-----------QF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQLSGSILWMAPEVIRM--------------------------------NPYS-FQSDVYAFGIVLYELMTG-----------------QLPYSN--I-----------------------------------------------NNRDQIIEMVGRG--SLSPDLSKVRSNCP-------------------------------------------------------------------------------------------------KRMKRLMAECLKKKRDERPS--------------FPRILAEIES
Activation segment
DFGLAT-----------QF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQLSGSILWMAPE
Binding pocket
QRIGSGSFGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQWCEGSSLYKHLHAYLHAKSIIHRDLKSNNIFLIGDFGLA
Ligand info
Orthosteric ligand
VQP
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7K0V, Chain A