7JY4 Chain A
ALK tyrosine kinase receptor (ALK)
Inactive — 0.9%DFG-inαC-inAllosteric,Type1 · W47
Resolution
2.42 Å
R-value
0.221
Predicted activity confidence0.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
YCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPI
UniProt reference sequence
ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEY
Aligned reference sequence
ITLI----------------RGLGHGA----------------FGEVYEGQV--SGMPNDP-------------------------------SPLQVAVKTLP--EVCSEQD---------------------------ELDFLMEALIISKF--------------------------NHQNIVRCIGVSLQSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRFILLELMAG--------------GDLKSFLRE--TRPRPSQPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLAMLDLLHVARDIACGCQYLEEN---------------------------------------------HFIHRDI-----AARNCLLTC--PGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRVAKIGDFGMARDIYRASYY--RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCAMLPVKWMPPEAFME--------------------------------GIFT-SKTDTWSFGVLLWEIFSL--G--------------YMPYPS--------------------------------------------------KSNQEVLEFVTSG--GRMDPPKNCP-----------------------------------------------------------------------------------------------------GPVYRIMTQCWQHQPEDRPN--------------FAIILERIEY
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLI----------------RGLGHGA----------------FGEVYEGQV----------------------------------------SPLQVAVKTLP--EVCSEQD---------------------------ELDFLMEALIISKF--------------------------NHQNIVRCIGVSLQSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRFILLELMAG--------------GDLKSFLRE--TRPRPSQPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLAMLDLLHVARDIACGCQYLEEN---------------------------------------------HFIHRDI-----AARNCLLTC--PGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRVAKIGDFGMARDIY---------G-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCAMLPVKWMPPEAFME--------------------------------GIFT-SKTDTWSFGVLLWEIFSL--G--------------YMPYPS--------------------------------------------------KSNQEVLEFVTSG--GRMDPPKNCP-----------------------------------------------------------------------------------------------------GPVYRIMTQCWQHQPEDRPN--------------FAIILERIEY
Activation segment
DFGMARDIY---------G-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCAMLPVKWMPPE
Binding pocket
RGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA
Ligand info
Orthosteric ligand
W47
Allosteric ligand
W47
Ligand typeAllosteric,Type1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7JY4, Chain A