7JXH Chain A
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Inactive — 0.0%DFG-inαC-outType1.5_Back · VOY
Resolution
3.27 Å
R-value
0.241
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
MPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNE
UniProt reference sequence
LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSR
Aligned reference sequence
LRKV----------------KVLGSGA----------------FGTVYKGIW--IPDGEN--------------------------------VKIPVAIKVLR--ENTSPKA---------------------------NKEILDEAYVMAGV--------------------------GSPYVSRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLVTQLMPY--------------GCLLDHVRE--NRG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLGSQDLLNWCMQIAKGMSYLEDV---------------------------------------------RLVHRDL-----AARNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNHVKITDFGLARLLDIDETE--YHA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGGKVPIKWMALESILR--------------------------------RRFT-HQSDVWSYGVTVWELMTF--G--------------AKPYDG--------------------------------------------------IPAREIPDLLEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDSECRPR--------------FRELVSEFSR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LRKV----------------KVLGSGA----------------FGTVYKGIW--IPDGEN--------------------------------VKIPVAIKVLR--ENTSPKA---------------------------NKEILDEAYVMAGV--------------------------GSPYVSRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLVTQLMPY--------------GCLLDHVRE--NRG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLGSQDLLNWCMQIAKGMSYLEDV---------------------------------------------RLVHRDL-----AARNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNHVKITDFGLAR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPIKWMALESILR--------------------------------RRFT-HQSDVWSYGVTVWELMTF--G--------------AKPYDG--------------------------------------------------IPAREIPDLLEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDSECRPR--------------FRELVSEFSR
Activation segment
DFGLAR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPIKWMALE
Binding pocket
KVLGSGAFGTVYKVAIKVLEILDEAYVMAGVGPYVSRLLGIQLVTQLMPYGCLLDHVREYLEDVRLVHRDLAARNVLVITDFGLA
Ligand info
Orthosteric ligand
VOY
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7JXH, Chain A