7JV1 Chain D
Kinase suppressor of Ras 1 (KSR1)
Inactive — 0.0%DFG-outαC-out
Resolution
3.62 Å
R-value
0.278
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues72
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
SVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLP
UniProt reference sequence
VELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEK
Aligned reference sequence
VELG----------------EPIGQGR----------------WGRVHRGRW-----------------------------------------HGEVAIRLLE--MDGHNQDH--------------------------LKLFKKEVMNYRQT--------------------------RHENVVLFMGACMNPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLAIITSFCKG--------------RTLHSFVRD--PKT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLDINKTRQIAQEIIKGMGYLHAK---------------------------------------------GIVHKDL-----KSKNVFYD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGKVVITDFGLFGISGVVREG--RRENQL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLSHDWLCYLAPEIVRE--MTPGKDEDQ---------------------LPFS-KAADVYAFGTVWYELQAR-----------------DWPLKN--------------------------------------------------QAAEASIWQIGSG--EGMKRVLTSVSLG--------------------------------------------------------------------------------------------------KEVSEILSACWAFDLQERPS--------------FSLLMDMLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VELG----------------EPIGQGR----------------WGRVHRGRW-----------------------------------------HGEVAIRLLE--MDGHNQDH--------------------------LKLFKKEVMNYRQT--------------------------RHENVVLFMGACMNPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLAIITSFCKG--------------RTLHSFVRD--PKT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLDINKTRQIAQEIIKGMGYLHAK---------------------------------------------GIVHKDL-----KSKNVFYD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGKVVITDFGLFGISGVV---------QL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLSHDWLCYLAPEIVRE--MTPGKDEDQ---------------------LPFS-KAADVYAFGTVWYELQAR-----------------DWPLKN--------------------------------------------------QAAEASIWQIGSG--EGMKRVLTSVSLG--------------------------------------------------------------------------------------------------KEVSEILSACWAFDLQERPS--------------FSLLMDMLEK
Activation segment
DFGLFGISGVV---------QL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLSHDWLCYLAPE
Binding pocket
EPIGQGRWGRVHR________________________________________________________________________
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7JV1, Chain D